Vascular mimetic microfluidic systems for the study of endothelial activation and leukocyte recruitment in models of atherogenesis

R. Michael Gower; Scott Simon

doi:10.1142/9789814280426_0013

Vascular mimetic microfluidic systems for the study of endothelial activation and leukocyte recruitment in models of atherogenesis

R. Michael Gower, Scott Simon

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Monocyte recruitment to inflamed endothelium is an early event in atherogenesis and occurs at focal regions where the average shear stress is on the order of one dyne/cm². Applying soft lithography to fabricate microfluidic channels that assemble above a living endothelial monolayer grown in culture, we have produced a vascular mimetic system that enables detailed studies of the influence of inflammation, hydrodynamics, and dietary lipid on the expression and function of vascular adhesion molecules.

Original language	English (US)
Title of host publication	Hemodynamics and Mechanobiology of Endothelium
Publisher	World Scientific Publishing Co.
Pages	313-329
Number of pages	17
ISBN (Electronic)	9789814280426
ISBN (Print)	9789814280419
DOIs	https://doi.org/10.1142/9789814280426_0013
State	Published - Jan 1 2010

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Engineering(all)
Medicine(all)

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10.1142/9789814280426_0013

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