Abstract
Monocyte recruitment to inflamed endothelium is an early event in atherogenesis and occurs at focal regions where the average shear stress is on the order of one dyne/cm2. Applying soft lithography to fabricate microfluidic channels that assemble above a living endothelial monolayer grown in culture, we have produced a vascular mimetic system that enables detailed studies of the influence of inflammation, hydrodynamics, and dietary lipid on the expression and function of vascular adhesion molecules.
| Original language | English (US) |
|---|---|
| Title of host publication | Hemodynamics and Mechanobiology of Endothelium |
| Publisher | World Scientific Publishing Co. |
| Pages | 313-329 |
| Number of pages | 17 |
| ISBN (Electronic) | 9789814280426 |
| ISBN (Print) | 9789814280419 |
| DOIs | |
| State | Published - Jan 1 2010 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Engineering(all)
- Medicine(all)
Cite this
Vascular mimetic microfluidic systems for the study of endothelial activation and leukocyte recruitment in models of atherogenesis. / Gower, R. Michael; Simon, Scott.
Hemodynamics and Mechanobiology of Endothelium. World Scientific Publishing Co., 2010. p. 313-329.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Vascular mimetic microfluidic systems for the study of endothelial activation and leukocyte recruitment in models of atherogenesis
AU - Gower, R. Michael
AU - Simon, Scott
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Monocyte recruitment to inflamed endothelium is an early event in atherogenesis and occurs at focal regions where the average shear stress is on the order of one dyne/cm2. Applying soft lithography to fabricate microfluidic channels that assemble above a living endothelial monolayer grown in culture, we have produced a vascular mimetic system that enables detailed studies of the influence of inflammation, hydrodynamics, and dietary lipid on the expression and function of vascular adhesion molecules.
AB - Monocyte recruitment to inflamed endothelium is an early event in atherogenesis and occurs at focal regions where the average shear stress is on the order of one dyne/cm2. Applying soft lithography to fabricate microfluidic channels that assemble above a living endothelial monolayer grown in culture, we have produced a vascular mimetic system that enables detailed studies of the influence of inflammation, hydrodynamics, and dietary lipid on the expression and function of vascular adhesion molecules.
UR - http://www.scopus.com/inward/record.url?scp=84986581315&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84986581315&partnerID=8YFLogxK
U2 - 10.1142/9789814280426_0013
DO - 10.1142/9789814280426_0013
M3 - Chapter
AN - SCOPUS:84986581315
SN - 9789814280419
SP - 313
EP - 329
BT - Hemodynamics and Mechanobiology of Endothelium
PB - World Scientific Publishing Co.
ER -