Abstract
Monocyte recruitment to inflamed endothelium is an early event in atherogenesis and occurs at focal regions where the average shear stress is on the order of one dyne/cm2. Applying soft lithography to fabricate microfluidic channels that assemble above a living endothelial monolayer grown in culture, we have produced a vascular mimetic system that enables detailed studies of the influence of inflammation, hydrodynamics, and dietary lipid on the expression and function of vascular adhesion molecules.
Original language | English (US) |
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Title of host publication | Hemodynamics and Mechanobiology of Endothelium |
Publisher | World Scientific Publishing Co. |
Pages | 313-329 |
Number of pages | 17 |
ISBN (Electronic) | 9789814280426 |
ISBN (Print) | 9789814280419 |
DOIs | |
State | Published - Jan 1 2010 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Engineering(all)
- Medicine(all)