Abstract
Monocyte recruitment to inflamed endothelium is an early event in atherogenesis and occurs at focal regions where the average shear stress is on the order of one dyne/cm2. Applying soft lithography to fabricate microfluidic channels that assemble above a living endothelial monolayer grown in culture, we have produced a vascular mimetic system that enables detailed studies of the influence of inflammation, hydrodynamics, and dietary lipid on the expression and function of vascular adhesion molecules.
| Original language | English (US) |
|---|---|
| Title of host publication | Hemodynamics and Mechanobiology of Endothelium |
| Publisher | World Scientific Publishing Co. |
| Pages | 313-329 |
| Number of pages | 17 |
| ISBN (Electronic) | 9789814280426 |
| ISBN (Print) | 9789814280419 |
| DOIs | |
| State | Published - Jan 1 2010 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Engineering(all)
- Medicine(all)
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Cite this
Gower, R. M., & Simon, S. (2010). Vascular mimetic microfluidic systems for the study of endothelial activation and leukocyte recruitment in models of atherogenesis. In Hemodynamics and Mechanobiology of Endothelium (pp. 313-329). World Scientific Publishing Co.. https://doi.org/10.1142/9789814280426_0013