Vascular mimetic microfluidic systems for the study of endothelial activation and leukocyte recruitment in models of atherogenesis

R. Michael Gower, Scott Simon

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Monocyte recruitment to inflamed endothelium is an early event in atherogenesis and occurs at focal regions where the average shear stress is on the order of one dyne/cm2. Applying soft lithography to fabricate microfluidic channels that assemble above a living endothelial monolayer grown in culture, we have produced a vascular mimetic system that enables detailed studies of the influence of inflammation, hydrodynamics, and dietary lipid on the expression and function of vascular adhesion molecules.

Original languageEnglish (US)
Title of host publicationHemodynamics and Mechanobiology of Endothelium
PublisherWorld Scientific Publishing Co.
Pages313-329
Number of pages17
ISBN (Electronic)9789814280426
ISBN (Print)9789814280419
DOIs
StatePublished - Jan 1 2010

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Microfluidics
Lithography
Lipids
Blood Vessels
Shear stress
Monolayers
Atherosclerosis
Leukocytes
Adhesion
Hydrodynamics
Chemical activation
Molecules
Endothelium
Monocytes
Inflammation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Medicine(all)

Cite this

Gower, R. M., & Simon, S. (2010). Vascular mimetic microfluidic systems for the study of endothelial activation and leukocyte recruitment in models of atherogenesis. In Hemodynamics and Mechanobiology of Endothelium (pp. 313-329). World Scientific Publishing Co.. https://doi.org/10.1142/9789814280426_0013

Vascular mimetic microfluidic systems for the study of endothelial activation and leukocyte recruitment in models of atherogenesis. / Gower, R. Michael; Simon, Scott.

Hemodynamics and Mechanobiology of Endothelium. World Scientific Publishing Co., 2010. p. 313-329.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gower, RM & Simon, S 2010, Vascular mimetic microfluidic systems for the study of endothelial activation and leukocyte recruitment in models of atherogenesis. in Hemodynamics and Mechanobiology of Endothelium. World Scientific Publishing Co., pp. 313-329. https://doi.org/10.1142/9789814280426_0013
Gower RM, Simon S. Vascular mimetic microfluidic systems for the study of endothelial activation and leukocyte recruitment in models of atherogenesis. In Hemodynamics and Mechanobiology of Endothelium. World Scientific Publishing Co. 2010. p. 313-329 https://doi.org/10.1142/9789814280426_0013
Gower, R. Michael ; Simon, Scott. / Vascular mimetic microfluidic systems for the study of endothelial activation and leukocyte recruitment in models of atherogenesis. Hemodynamics and Mechanobiology of Endothelium. World Scientific Publishing Co., 2010. pp. 313-329
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