Vascular endothelial growth factor mRNA expression and peritumoral edema in canine primary central nervous system tumors

Peter J Dickinson, Beverly Sturges, Robert Higgins, B. N. Roberts, C. M. Leutenegger, A. W. Bollen, Richard A Lecouteur

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Vascular endothelial growth factor (VEGF) is an important regulator of tumor angiogenesis and vascular permeability, and has been implicated both in progression of central nervous system (CNS) tumors and development of vasogenic peritumoral edema. A retrospective study was done to characterize the levels of expression of the 3 major canine VEGF isoforms (VEGF120, VEGF 164, VEGF188) in a variety of spontaneous canine CNS tumors using quantitative TaqMan reverse transcription real-time polymerase chain reaction. Presence and degree of peritumoral edema also were determined in sampled tumors using magnetic resonance imaging (MRI). Increased expression of VEGF relative to normal cerebral cortex tissue was seen predominantly in high grade astrocytic (grade IV) and oligodendroglial (grade III) tumors, with lower expression in low grade astrocytomas (grade II) and meningiomas (grade I). All 3 major VEGF isoforms were present; VEGF164 was the predominant isoform, particularly in the tumors with the highest VEGF expression. Peritumoral edema was present in all tumor types; however, a significant association between the extent of peritumoral edema and the level of VEGF expression was not apparent.

Original languageEnglish (US)
Pages (from-to)131-139
Number of pages9
JournalVeterinary Pathology
Volume45
Issue number2
DOIs
StatePublished - Mar 2008

Keywords

  • Canine
  • Central nervous system tumors
  • Edema
  • Reverse transcriptase polymerase chain reaction
  • Vascular endothelial growth factor
  • VEGF

ASJC Scopus subject areas

  • veterinary(all)

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