Vascular Endothelial Growth Factor Causes Endothelial Proliferation After Vascular Injury

P. A. Burke, K. Lehmannbruinsma, Jerry S Powell

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Vascular endothelial growth factor was infused into rat carotid arteries for 3 minutes immediately after endothelial denudation by balloon injury. Endothelial proliferation was determined by immunohistochemical labelling of proliferating cell nuclear antigen using Häutchen preparations. The proliferation index, or number of proliferating cells/total cells, measured at 25.5 or 30 hours was markedly increased after infusion of vascular endothelial growth factor. In addition, the total number of proliferating cells increased with increasing doses up to 100μg total dose per infusion. These data indicate that infusion of vascular endothelial growth factor increases endothelial cell proliferation after mechanical denudation injury of the vascular wall.

Original languageEnglish (US)
Pages (from-to)348-354
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume207
Issue number1
DOIs
StatePublished - Feb 6 1995

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Vascular System Injuries
Vascular Endothelial Growth Factor A
Cell Count
Balloons
Endothelial cells
Proliferating Cell Nuclear Antigen
Cell proliferation
Carotid Arteries
Labeling
Rats
Endothelial Cells
Cell Proliferation
Wounds and Injuries

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Biophysics
  • Biochemistry

Cite this

Vascular Endothelial Growth Factor Causes Endothelial Proliferation After Vascular Injury. / Burke, P. A.; Lehmannbruinsma, K.; Powell, Jerry S.

In: Biochemical and Biophysical Research Communications, Vol. 207, No. 1, 06.02.1995, p. 348-354.

Research output: Contribution to journalArticle

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