Vascular Dementia

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cerebrovascular disease is currently viewed as a distinctly secondary cause of dementia that is of uncertain importance. Although it is commonly cited as the second leading cause of dementia, a lack of well-validated diagnostic criteria, Which in turn reflects important gaps in fundamental knowledge about disease mechanisms, makes accurate epidemiology difficult. Two basic facts about vascular dementia share wide consensus. First, it is a disorder in which the pathologic features vary, spanning a wide spectrum in terms of type (from microscopic infarction to infarcts that derive from occlusion of major arteries) and location. Second, the pathologies of cerebrovascular disease and Alzheimer disease (AD) commonly co-occur, the latter being the usual primary cause of the cognitive and functional symptoms of these patients. Indeed, AD, as the predominant cause of dementia in North America and Europe, defines the backdrop against which research on vascular dementia proceeds. There is little interest in large cortical strokes as a cause of dementia, because the pathogenesis is apparent and the clinical issues are largely distinct from those of AD. It is dementia associated with small vessel disease in which the pathogenesis is not apparent and in which the differentiation from AD is difficult that has attracted most attention from researchers in dementia.

Original languageEnglish (US)
Pages (from-to)433-435
Number of pages3
JournalArchives of Neurology
Volume61
Issue number3
DOIs
StatePublished - Mar 2004

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Vascular Dementia
Dementia
Alzheimer Disease
Cerebrovascular Disorders
Neurobehavioral Manifestations
North America
Infarction
Consensus
Epidemiology
Arteries
Stroke
Research Personnel
Pathology
Causes
Research
Alzheimer's Disease

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Vascular Dementia. / Reed, Bruce R.

In: Archives of Neurology, Vol. 61, No. 3, 03.2004, p. 433-435.

Research output: Contribution to journalArticle

Reed, Bruce R. / Vascular Dementia. In: Archives of Neurology. 2004 ; Vol. 61, No. 3. pp. 433-435.
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