Abstract
HDL cholesterol (C) is an established negative risk factor for cardiovascular disease. Low levels of HDLC, often associated with insulin resistance, are frequently seen in subjects with high plasma triglycerides (TG). To study dietary effects on HDLC levels and HDL subclass pattern, 86 subjects with low HDLC and/or high TG and/or high insulin levels were recruited for a dietary study using the DELTA multicenter randomized 3-way crossover design. Each subject consumed three different diets for 7 weeks; an average American diet, AAD (36% total fat (TF); 16% saturated fat (SFA); 14% monounsaturated fat (MUFA); 48% carbohydrate (CHO)); the AHA Step I diet (29% TF; 8% SFA; 15% MUFA; 55% CHO); and a high MUFA diet (36% TF; 9% SFA; 21% MUFA; 48% CHO). HDLC levels (mg/dl) fell in a step-wise fashion as dietary SFA and TF were reduced (AAD: 42.5; MUFA: 40.8; Step I: 39.3). HDL2 levels (mg/dl) decreased in parallel with overall HDLC levels (AAD: 17.8; MUFA: 16.9; Step I: 16.1). HDL3 levels did not differ between AAD and MUFA, but were lower during the Step I diet. Thus, changes in HDL2 levels reflected changes in HDLC when reducing TF and SFA in subjects at risk for hyperTG or diaTjetes; the effect of the high MUFA diet was less pronounced than that of the Step I diet.
| Original language | English (US) |
|---|---|
| Journal | FASEB Journal |
| Volume | 10 |
| Issue number | 3 |
| State | Published - 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Cell Biology
Cite this
Variation of hdl subclass pattern during dietary intervention in subjects with markers for insulin resistance. / Berglund, Lars.
In: FASEB Journal, Vol. 10, No. 3, 1996.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Variation of hdl subclass pattern during dietary intervention in subjects with markers for insulin resistance
AU - Berglund, Lars
PY - 1996
Y1 - 1996
N2 - HDL cholesterol (C) is an established negative risk factor for cardiovascular disease. Low levels of HDLC, often associated with insulin resistance, are frequently seen in subjects with high plasma triglycerides (TG). To study dietary effects on HDLC levels and HDL subclass pattern, 86 subjects with low HDLC and/or high TG and/or high insulin levels were recruited for a dietary study using the DELTA multicenter randomized 3-way crossover design. Each subject consumed three different diets for 7 weeks; an average American diet, AAD (36% total fat (TF); 16% saturated fat (SFA); 14% monounsaturated fat (MUFA); 48% carbohydrate (CHO)); the AHA Step I diet (29% TF; 8% SFA; 15% MUFA; 55% CHO); and a high MUFA diet (36% TF; 9% SFA; 21% MUFA; 48% CHO). HDLC levels (mg/dl) fell in a step-wise fashion as dietary SFA and TF were reduced (AAD: 42.5; MUFA: 40.8; Step I: 39.3). HDL2 levels (mg/dl) decreased in parallel with overall HDLC levels (AAD: 17.8; MUFA: 16.9; Step I: 16.1). HDL3 levels did not differ between AAD and MUFA, but were lower during the Step I diet. Thus, changes in HDL2 levels reflected changes in HDLC when reducing TF and SFA in subjects at risk for hyperTG or diaTjetes; the effect of the high MUFA diet was less pronounced than that of the Step I diet.
AB - HDL cholesterol (C) is an established negative risk factor for cardiovascular disease. Low levels of HDLC, often associated with insulin resistance, are frequently seen in subjects with high plasma triglycerides (TG). To study dietary effects on HDLC levels and HDL subclass pattern, 86 subjects with low HDLC and/or high TG and/or high insulin levels were recruited for a dietary study using the DELTA multicenter randomized 3-way crossover design. Each subject consumed three different diets for 7 weeks; an average American diet, AAD (36% total fat (TF); 16% saturated fat (SFA); 14% monounsaturated fat (MUFA); 48% carbohydrate (CHO)); the AHA Step I diet (29% TF; 8% SFA; 15% MUFA; 55% CHO); and a high MUFA diet (36% TF; 9% SFA; 21% MUFA; 48% CHO). HDLC levels (mg/dl) fell in a step-wise fashion as dietary SFA and TF were reduced (AAD: 42.5; MUFA: 40.8; Step I: 39.3). HDL2 levels (mg/dl) decreased in parallel with overall HDLC levels (AAD: 17.8; MUFA: 16.9; Step I: 16.1). HDL3 levels did not differ between AAD and MUFA, but were lower during the Step I diet. Thus, changes in HDL2 levels reflected changes in HDLC when reducing TF and SFA in subjects at risk for hyperTG or diaTjetes; the effect of the high MUFA diet was less pronounced than that of the Step I diet.
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UR - http://www.scopus.com/inward/citedby.url?scp=33749124720&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:33749124720
VL - 10
JO - FASEB Journal
JF - FASEB Journal
SN - 0892-6638
IS - 3
ER -