Variation of hdl subclass pattern during dietary intervention in subjects with markers for insulin resistance

Research output: Contribution to journalArticle

Abstract

HDL cholesterol (C) is an established negative risk factor for cardiovascular disease. Low levels of HDLC, often associated with insulin resistance, are frequently seen in subjects with high plasma triglycerides (TG). To study dietary effects on HDLC levels and HDL subclass pattern, 86 subjects with low HDLC and/or high TG and/or high insulin levels were recruited for a dietary study using the DELTA multicenter randomized 3-way crossover design. Each subject consumed three different diets for 7 weeks; an average American diet, AAD (36% total fat (TF); 16% saturated fat (SFA); 14% monounsaturated fat (MUFA); 48% carbohydrate (CHO)); the AHA Step I diet (29% TF; 8% SFA; 15% MUFA; 55% CHO); and a high MUFA diet (36% TF; 9% SFA; 21% MUFA; 48% CHO). HDLC levels (mg/dl) fell in a step-wise fashion as dietary SFA and TF were reduced (AAD: 42.5; MUFA: 40.8; Step I: 39.3). HDL2 levels (mg/dl) decreased in parallel with overall HDLC levels (AAD: 17.8; MUFA: 16.9; Step I: 16.1). HDL3 levels did not differ between AAD and MUFA, but were lower during the Step I diet. Thus, changes in HDL2 levels reflected changes in HDLC when reducing TF and SFA in subjects at risk for hyperTG or diaTjetes; the effect of the high MUFA diet was less pronounced than that of the Step I diet.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996
Externally publishedYes

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monounsaturated fatty acids
eating habits
insulin resistance
Insulin Resistance
Fats
Insulin
diet
Nutrition
lipids
diet study techniques
Diet
triacylglycerols
High Fat Diet
high density lipoprotein cholesterol
cardiovascular diseases
Triglycerides
insulin
risk factors
saturated fats
carbohydrates

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

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title = "Variation of hdl subclass pattern during dietary intervention in subjects with markers for insulin resistance",
abstract = "HDL cholesterol (C) is an established negative risk factor for cardiovascular disease. Low levels of HDLC, often associated with insulin resistance, are frequently seen in subjects with high plasma triglycerides (TG). To study dietary effects on HDLC levels and HDL subclass pattern, 86 subjects with low HDLC and/or high TG and/or high insulin levels were recruited for a dietary study using the DELTA multicenter randomized 3-way crossover design. Each subject consumed three different diets for 7 weeks; an average American diet, AAD (36{\%} total fat (TF); 16{\%} saturated fat (SFA); 14{\%} monounsaturated fat (MUFA); 48{\%} carbohydrate (CHO)); the AHA Step I diet (29{\%} TF; 8{\%} SFA; 15{\%} MUFA; 55{\%} CHO); and a high MUFA diet (36{\%} TF; 9{\%} SFA; 21{\%} MUFA; 48{\%} CHO). HDLC levels (mg/dl) fell in a step-wise fashion as dietary SFA and TF were reduced (AAD: 42.5; MUFA: 40.8; Step I: 39.3). HDL2 levels (mg/dl) decreased in parallel with overall HDLC levels (AAD: 17.8; MUFA: 16.9; Step I: 16.1). HDL3 levels did not differ between AAD and MUFA, but were lower during the Step I diet. Thus, changes in HDL2 levels reflected changes in HDLC when reducing TF and SFA in subjects at risk for hyperTG or diaTjetes; the effect of the high MUFA diet was less pronounced than that of the Step I diet.",
author = "Lars Berglund",
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TY - JOUR

T1 - Variation of hdl subclass pattern during dietary intervention in subjects with markers for insulin resistance

AU - Berglund, Lars

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N2 - HDL cholesterol (C) is an established negative risk factor for cardiovascular disease. Low levels of HDLC, often associated with insulin resistance, are frequently seen in subjects with high plasma triglycerides (TG). To study dietary effects on HDLC levels and HDL subclass pattern, 86 subjects with low HDLC and/or high TG and/or high insulin levels were recruited for a dietary study using the DELTA multicenter randomized 3-way crossover design. Each subject consumed three different diets for 7 weeks; an average American diet, AAD (36% total fat (TF); 16% saturated fat (SFA); 14% monounsaturated fat (MUFA); 48% carbohydrate (CHO)); the AHA Step I diet (29% TF; 8% SFA; 15% MUFA; 55% CHO); and a high MUFA diet (36% TF; 9% SFA; 21% MUFA; 48% CHO). HDLC levels (mg/dl) fell in a step-wise fashion as dietary SFA and TF were reduced (AAD: 42.5; MUFA: 40.8; Step I: 39.3). HDL2 levels (mg/dl) decreased in parallel with overall HDLC levels (AAD: 17.8; MUFA: 16.9; Step I: 16.1). HDL3 levels did not differ between AAD and MUFA, but were lower during the Step I diet. Thus, changes in HDL2 levels reflected changes in HDLC when reducing TF and SFA in subjects at risk for hyperTG or diaTjetes; the effect of the high MUFA diet was less pronounced than that of the Step I diet.

AB - HDL cholesterol (C) is an established negative risk factor for cardiovascular disease. Low levels of HDLC, often associated with insulin resistance, are frequently seen in subjects with high plasma triglycerides (TG). To study dietary effects on HDLC levels and HDL subclass pattern, 86 subjects with low HDLC and/or high TG and/or high insulin levels were recruited for a dietary study using the DELTA multicenter randomized 3-way crossover design. Each subject consumed three different diets for 7 weeks; an average American diet, AAD (36% total fat (TF); 16% saturated fat (SFA); 14% monounsaturated fat (MUFA); 48% carbohydrate (CHO)); the AHA Step I diet (29% TF; 8% SFA; 15% MUFA; 55% CHO); and a high MUFA diet (36% TF; 9% SFA; 21% MUFA; 48% CHO). HDLC levels (mg/dl) fell in a step-wise fashion as dietary SFA and TF were reduced (AAD: 42.5; MUFA: 40.8; Step I: 39.3). HDL2 levels (mg/dl) decreased in parallel with overall HDLC levels (AAD: 17.8; MUFA: 16.9; Step I: 16.1). HDL3 levels did not differ between AAD and MUFA, but were lower during the Step I diet. Thus, changes in HDL2 levels reflected changes in HDLC when reducing TF and SFA in subjects at risk for hyperTG or diaTjetes; the effect of the high MUFA diet was less pronounced than that of the Step I diet.

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