Variation in virulence of West Nile virus strains for house sparrows (Passer Domesticus)

Stanley A. Langevin; Aaron Brault; Nicholas A. Panella; Richard A. Bowen; Nicholas Komar

Variation in virulence of West Nile virus strains for house sparrows (Passer Domesticus)

Stanley A. Langevin, Aaron Brault, Nicholas A. Panella, Richard A. Bowen, Nicholas Komar

School of Veterinary Medicine

Research output: Contribution to journal › Article

64 Scopus citations

Abstract

The observation of avian mortality associated with West Nile virus (WNV) infection has become a hallmark epidemiologic feature in the recent emergence of this pathogen in Israel and North America. To determine if phenotypic differences exist among different WNV isolates, we exposed house sparrows (Passer domesticus) to low passage, lineage 1 WNV strains from North America (NY99), Kenya (KEN), and Australia (KUN; also known as Kunjin virus). House sparrows inoculated with the NY99 and KEN strains experienced similar mortality rates and viremia profiles. The KUN strain elicited significantly lower-titered viremia when compared with the other strains and induced no mortality. This study suggests that natural mortality in house sparrows due to Old World strains of WNV may be occurring where the KEN strain occurs.

Original language	English (US)
Pages (from-to)	99-102
Number of pages	4
Journal	American Journal of Tropical Medicine and Hygiene
Volume	72
Issue number	1
State	Published - Jan 1 2005

ASJC Scopus subject areas

Parasitology
Infectious Diseases
Virology

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Langevin, S. A., Brault, A., Panella, N. A., Bowen, R. A., & Komar, N. (2005). Variation in virulence of West Nile virus strains for house sparrows (Passer Domesticus). American Journal of Tropical Medicine and Hygiene, 72(1), 99-102.

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