Variant responses of mice to Borrelia burgdorferi depending on the site of intradermal inoculation

M. S. De Souza, A. L. Smith, D. S. Beck, L. J. Kim, G. M. Hansen, Stephen W Barthold

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

C3H/He mice inoculated intradermally at one of two sites with Borrelia burgdorferi responded differently to infection. Shoulder-inoculated mice developed spirochetemia, B. burgdorferi-specific antibody, and arthritis earlier than foot-inoculated mice. Lymphocyte populations derived from spleen tissue were elevated in the shoulder- but not the foot-inoculated mice, and those from lymph nodes were increased in both groups. Lymphocytes derived from blood and spleen tissue showed impaired proliferative responses to all mitogens for shoulder-inoculated mice only, whereas proliferation of lymph node cells was not affected, regardless of route. These results demonstrate that the site of initial B. burgdorferi inoculation is an important determinant in the pathogenesis of B. burgdorferi infection.

Original languageEnglish (US)
Pages (from-to)4493-4497
Number of pages5
JournalInfection and Immunity
Volume61
Issue number10
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Variant responses of mice to Borrelia burgdorferi depending on the site of intradermal inoculation'. Together they form a unique fingerprint.

Cite this