Variable effects of nitrous oxide at multiple levels of the central nervous system in goats

J. F. Antognini, X. G. Chen, M. Sudo, S. Sudo, Earl Carstens

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The direct and indirect effects of nitrous oxide (N2O) on the nociceptive responses of lumbar dorsal horn neurons, and the indirect effects on midbrain reticular formation (MRF) neurons and thalamic neurons were determined in goats anaesthetized with isoflurane. The technique used enabled the differential delivery of N2O to either the torso or the cerebral circulation, thus allowing assessment of the direct spinal and indirect brain effects of N2O. Systemic delivery of N2O appeared to have divergent effects, facilitating (4/11) or depressing (7/11) the responses of dorsal horn neurons. Such divergent effects were also observed when N2O was differentially delivered to the circulation in the torso (i.e. the spinal cord). Likewise, MRF and thalamic responses to noxious stimulation were variably affected by administration of N2O to the torso, with some cells facilitated (7/13 MRF neurons, 3/8 thalamic neurons) and others depressed (6/13 MRF neurons, 5/8 thalamic neurons). It appears that N2O has variable effects on the caprine CNS. The facilitatory action of N2O might partially explain why it is a relatively weak anaesthetic.

Original languageEnglish (US)
Pages (from-to)523-538
Number of pages16
JournalVeterinary Research Communications
Volume25
Issue number7
DOIs
StatePublished - 2001

Fingerprint

Nitrous Oxide
nitrous oxide
Goats
central nervous system
Central Nervous System
goats
neurons
Neurons
Torso
torso
Posterior Horn Cells
brain
Cerebrovascular Circulation
Isoflurane
Anesthetics
Spinal Cord
isoflurane
spinal cord
anesthetics
Midbrain Reticular Formation

Keywords

  • Depression
  • Dorsal horn
  • Facilitation
  • Goats
  • Midbrain
  • Neurons
  • Nitrous oxide
  • Nociception
  • Site of action
  • Spinal cord
  • Thalamus

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Variable effects of nitrous oxide at multiple levels of the central nervous system in goats. / Antognini, J. F.; Chen, X. G.; Sudo, M.; Sudo, S.; Carstens, Earl.

In: Veterinary Research Communications, Vol. 25, No. 7, 2001, p. 523-538.

Research output: Contribution to journalArticle

Antognini, J. F. ; Chen, X. G. ; Sudo, M. ; Sudo, S. ; Carstens, Earl. / Variable effects of nitrous oxide at multiple levels of the central nervous system in goats. In: Veterinary Research Communications. 2001 ; Vol. 25, No. 7. pp. 523-538.
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