Variability of serum antibody responses of goat kids to a commercial Clostridium perfringens epsilon toxoid vaccine

Twenty-nine Angora goats were used in a trial of a commercial enterotoxaemia (pulpy kidney disease) vaccine. The animals were allocated to four groups, of which three received an initial dose of vaccine, two also received a booster of the same vaccine either 28 or 42 days after the first vaccination, and the fourth remained as an unvaccinated control group. An indirect ELISA technique was used to measure the titres of Clostridium perfringens type D epsilon antitoxin in serum samples taken before vaccination and 17, 28, 42, 59, 70, 86, 98 and 128 days after vaccination. There was a wide range of antibody titres after vaccination, and the great majority of the vaccinated animals had titres below the protective level, arbitrarily set at 0.25 iu/ml, by day 98.