Variability of cellular biomechanical properties as a function of substrate matrix type

D. Shin, J. Schmitz, T. Lee, C. M. Agrawal, K. A. Athanasiou

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An experiment was conducted to obtain the intrinsic material properties of the individual cell as a function of the type of substrate matrix and to investigate fundamental aspects of the response mechanism of individual cells to alterations in their biophysical environment. Using the cytointender, the effects of the three substrates (glass, Matrigel, and poly-D-lysine) were examined on the mechanical properties of 23 MG63 cells (human osteosarcoma). Cells grown on glass coated with poly-D-lysine showed significant increase in all the intrinsic indices of stiffness and the structural stiffness, when compared to the other two substrates. Its Poisson's ratio was also the smallest. In contrast, MG63 cells grown on glass were the softest.

Original languageEnglish (US)
Title of host publicationSouthern Biomedical Engineering Conference - Proceedings
Place of PublicationPiscataway, NJ, United States
PublisherIEEE
Pages62
Number of pages1
StatePublished - 1998
Externally publishedYes
EventProceedings of the 1998 17th Southern Biomedical Engineering Conference - San Antonio, TX, USA
Duration: Feb 6 1998Feb 8 1998

Other

OtherProceedings of the 1998 17th Southern Biomedical Engineering Conference
CitySan Antonio, TX, USA
Period2/6/982/8/98

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Shin, D., Schmitz, J., Lee, T., Agrawal, C. M., & Athanasiou, K. A. (1998). Variability of cellular biomechanical properties as a function of substrate matrix type. In Southern Biomedical Engineering Conference - Proceedings (pp. 62). IEEE.