Variability in PolyIC induced immune response

Implications for preclinical maternal immune activation models

Milo Careaga, Sandra L. Taylor, Carolyn Chang, Alex Chiang, Katherine M. Ku, Robert F Berman, Judith A Van de Water, Melissa D Bauman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Maternal infection during pregnancy may increase the risk of offspring neurodevelopmental disorders. The preclinical Polyinosinic-polycytidylic acid (PolyIC) model has become one of the most widely used approaches in maternal immune activation (MIA) research. However, variability in molecular weight may impact the immune activating potential of PolyIC. Nulliparous rats injected with high molecular weight PolyIC exhibit pronounced cytokine response and sickness behavior that was not observed in rats injected low molecular weight PolyIC. Although an essential next step is to extend these studies to pregnant animals, the preliminary results suggest that PolyIC molecular weight is an important experimental design consideration.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalJournal of Neuroimmunology
Volume323
DOIs
StatePublished - Oct 15 2018

Fingerprint

Poly C
Molecular Weight
Mothers
Illness Behavior
Poly I-C
Research Design
Cytokines
Pregnancy
Infection
Research

Keywords

  • Cytokine
  • Immune
  • Maternal immune activation
  • PolyIC
  • Polyinosinic-polycytidylic acid
  • Sickness behavior

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Variability in PolyIC induced immune response : Implications for preclinical maternal immune activation models. / Careaga, Milo; Taylor, Sandra L.; Chang, Carolyn; Chiang, Alex; Ku, Katherine M.; Berman, Robert F; Van de Water, Judith A; Bauman, Melissa D.

In: Journal of Neuroimmunology, Vol. 323, 15.10.2018, p. 87-93.

Research output: Contribution to journalArticle

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