Variability in FMRP and early development in males with fragile X syndrome

Jr Bailey D.B., D. D. Hatton, Flora Tassone, M. Skinner, A. K. Taylor

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

To test the hypothesis that variability in development in fragile X syndrome is related to FMRP (the protein deficient in this syndrome expression), we studied 53 males between 23 and 98 months of age. For the entire group, which included males with either mosaism, partially methylated full mutation, and fully methylated full mutation, FMRP expression ranged from 1% to 40% and accounted for a small but significant amount of variance in level, but not rate, of total development as well as motor, social, adaptive, cognitive, and language development. For males with a fully methylated full mutation, the association was in the hypothesized direction, but not statistically significant. Findings support the hypothesized relationship between FMRP and individual capabilities but suggest that other factors also play a major role.

Original languageEnglish (US)
Pages (from-to)16-27
Number of pages12
JournalAmerican Journal on Mental Retardation
Volume106
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Rehabilitation
  • Health Professions(all)
  • Education

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