VALUE OF NECROPSY IN ACQUIRED IMMUNODEFICIENCY SYNDROME

Michael S Wilkes, Juan C. Felix, Auguste H. Fortin, Thomas A. Godwin, Warren G. Thompson

Research output: Contribution to journalArticle

123 Scopus citations

Abstract

Necropsy findings in 101 adult patients with the acquired immunodeficiency syndrome (AIDS) from two metropolitan hospitals were compared retrospectively with the antemortem clinical diagnoses. 94% of the patients were male and 68% were homosexual or bisexual. 75 (74%) patients had AIDS-related diseases at necropsy that were not suspected clinically. The commonest of the unsuspected AIDS-related diseases were cytomegalovirus infection (49% of all cases), systemic fungal infection (20%), systemic Kaposi's sarcoma (14%), Mycobacterium avium intracellulareinfection (11%), and systemic herpes infection (9%). Cryptococcal infection and cytomegalovirus retinitis were always diagnosed antemortem; and Pneumocystis cariniipneumonia went undiagnosed in only 5 of 58 (9%) patients who had proven infection either clinically or at necropsy. 8 patients who died with fungal pneumonia had undergone bronchoscopy; however, in only 1 patient was it diagnosed antemortem. Tuberculosis was undiagnosed in 4 patients. 4 cases of central nervous system lymphoma diagnosed only at necropsy had been treated empirically for toxoplasmosis. Bacterial pneumonias contributed considerably to mortality in 30% of the patients.

Original languageEnglish (US)
Pages (from-to)85-88
Number of pages4
JournalThe Lancet
Volume332
Issue number8602
DOIs
StatePublished - Jul 9 1988
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Wilkes, M. S., Felix, J. C., Fortin, A. H., Godwin, T. A., & Thompson, W. G. (1988). VALUE OF NECROPSY IN ACQUIRED IMMUNODEFICIENCY SYNDROME. The Lancet, 332(8602), 85-88. https://doi.org/10.1016/S0140-6736(88)90014-1