Abstract
Valproic acid has been reported to be very effective against kindled amygdaloid Scizures in several species. In this study, the anticonvulsant effectiveness of valproic acid against kindled amygdaloid Scizures was studied in a systematic, multiple-dose evaluation in rats. A correlation at 30 min. between the degree of Scizure protection and increased serum levels of valproic acid was seen. At 30 min., the fifty percent effective dose (ED50) was found to be 200 mg/kg. Additionally, the fifty percent effective serum level (ESL50) was estimated to be 500 mg/L.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 95-97 |
| Number of pages | 3 |
| Journal | Neuropharmacology |
| Volume | 20 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1981 |
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ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Drug Discovery
- Pharmacology
Cite this
Valproic acid serum levels and protection against kindled amygdaloid scizures in the rat. / Albertson, Timothy E; Peterson, S. L.; Stark, L. G.; Baselt, R. C.
In: Neuropharmacology, Vol. 20, No. 1, 1981, p. 95-97.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Valproic acid serum levels and protection against kindled amygdaloid scizures in the rat
AU - Albertson, Timothy E
AU - Peterson, S. L.
AU - Stark, L. G.
AU - Baselt, R. C.
PY - 1981
Y1 - 1981
N2 - Valproic acid has been reported to be very effective against kindled amygdaloid Scizures in several species. In this study, the anticonvulsant effectiveness of valproic acid against kindled amygdaloid Scizures was studied in a systematic, multiple-dose evaluation in rats. A correlation at 30 min. between the degree of Scizure protection and increased serum levels of valproic acid was seen. At 30 min., the fifty percent effective dose (ED50) was found to be 200 mg/kg. Additionally, the fifty percent effective serum level (ESL50) was estimated to be 500 mg/L.
AB - Valproic acid has been reported to be very effective against kindled amygdaloid Scizures in several species. In this study, the anticonvulsant effectiveness of valproic acid against kindled amygdaloid Scizures was studied in a systematic, multiple-dose evaluation in rats. A correlation at 30 min. between the degree of Scizure protection and increased serum levels of valproic acid was seen. At 30 min., the fifty percent effective dose (ED50) was found to be 200 mg/kg. Additionally, the fifty percent effective serum level (ESL50) was estimated to be 500 mg/L.
UR - http://www.scopus.com/inward/record.url?scp=0019352492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019352492&partnerID=8YFLogxK
U2 - 10.1016/0028-3908(81)90050-2
DO - 10.1016/0028-3908(81)90050-2
M3 - Article
C2 - 6783975
AN - SCOPUS:0019352492
VL - 20
SP - 95
EP - 97
JO - Neuropharmacology
JF - Neuropharmacology
SN - 0028-3908
IS - 1
ER -