Valproic acid serum levels and protection against kindled amygdaloid scizures in the rat

Timothy E Albertson, S. L. Peterson, L. G. Stark, R. C. Baselt

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Valproic acid has been reported to be very effective against kindled amygdaloid Scizures in several species. In this study, the anticonvulsant effectiveness of valproic acid against kindled amygdaloid Scizures was studied in a systematic, multiple-dose evaluation in rats. A correlation at 30 min. between the degree of Scizure protection and increased serum levels of valproic acid was seen. At 30 min., the fifty percent effective dose (ED50) was found to be 200 mg/kg. Additionally, the fifty percent effective serum level (ESL50) was estimated to be 500 mg/L.

Original languageEnglish (US)
Pages (from-to)95-97
Number of pages3
JournalNeuropharmacology
Volume20
Issue number1
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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