Validity of self-reported stroke in elderly African Americans, Caribbean Hispanics, and Whites

Christiane Reitz, Nicole Schupf, José A. Luchsinger, Adam M. Brickman, Jennifer J. Manly, Howard Andrews, Ming X. Tang, Charles DeCarli, Truman R. Brown, Richard Mayeux

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Abstract

Background: The validity of a self-reported stroke remains inconclusive. Objective: To validate the diagnosis of self-reported stroke using stroke identified by magnetic resonance imaging (MRI) as the standard. Design, Setting, and Participants: Community-based cohort study of nondemented, ethnically diverse elderly persons in northern Manhattan. Methods: High-resolution quantitative MRIs were acquired for 717 participants without dementia. Sensitivity and specificity of stroke by self-report were examined using cross-sectional analyses and the χ2 test. Putative relationships between factors potentially influencing the reporting of stroke, including memory performance, cognitive function, and vascular risk factors, were assessed using logistic regression models. Subsequently, all analyses were repeated, stratified by age, sex, ethnic group, and level of education. Results: In analyses of the whole sample, sensitivity of stroke self-report for a diagnosis of stroke on MRI was 32.4%, and specificity was 78.9%. In analyses stratified by median age (80.1 years), the validity between reported stroke and detection of stroke on MRI was significantly better in the younger than the older age group (for all vascular territories: sensitivity and specificity, 36.7% and 81.3% vs 27.6% and 26.2%; P = .02). Impaired memory, cognitive skills, or language ability and the presence of hypertension or myocardial infarction were associated with higher rates of false-negative results. Conclusions: Using brain MRI as the standard, specificity and sensitivity of stroke self-report are low. Accuracy of self-report is influenced by age, presence of vascular disease, and cognitive function. In stroke research, sensitive neuroimaging techniques rather than stroke self-report should be used to determine stroke history.

Original languageEnglish (US)
Pages (from-to)834-840
Number of pages7
JournalArchives of Neurology
Volume66
Issue number7
DOIs
StatePublished - Jul 2009

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ASJC Scopus subject areas

  • Clinical Neurology

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Reitz, C., Schupf, N., Luchsinger, J. A., Brickman, A. M., Manly, J. J., Andrews, H., Tang, M. X., DeCarli, C., Brown, T. R., & Mayeux, R. (2009). Validity of self-reported stroke in elderly African Americans, Caribbean Hispanics, and Whites. Archives of Neurology, 66(7), 834-840. https://doi.org/10.1001/archneurol.2009.83