Validation of the PROMIS physical function measures in a diverse US population-based cohort of cancer patients

Roxanne E. Jensen, Arnold L. Potosky, Bryce B. Reeve, Elizabeth Hahn, David Cella, James Fries, Ashley Wilder Smith, Theresa H Keegan, Xiao Cheng Wu, Lisa Paddock, Carol M. Moinpour

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


Purpose: To evaluate the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) physical function measures in a diverse, population-based cancer sample. Methods: Cancer patients 6–13 months post-diagnosis (n = 4840) were recruited for the Measuring Your Health study. Participants were diagnosed between 2010 and 2013 with non-Hodgkin lymphoma or cancers of the colorectum, lung, breast, uterus, cervix, or prostate. Four PROMIS physical function short forms (4a, 6b, 10a, and 16) were evaluated for validity and reliability across age and race–ethnicity groups. Covariates included gender, marital status, education level, cancer site and stage, comorbidities, and functional status. Results: PROMIS physical function short forms showed high internal consistency (Cronbach’s α = 0.92–0.96), convergent validity (fatigue, pain interference, FACT physical well-being all r ≥ 0.68), and discriminant validity (unrelated domains all r ≤ 0.3) across survey short forms, age, and race–ethnicity. Known-group differences by demographic, clinical, and functional characteristics performed as hypothesized. Ceiling effects for higher-functioning individuals were identified on most forms. Conclusions: This study provides strong evidence that PROMIS physical function measures are valid and reliable in multiple race–ethnicity and age groups. Researchers selecting specific PROMIS short forms should consider the degree of functional disability in their patient population to ensure that length and content are tailored to limit response burden.

Original languageEnglish (US)
Pages (from-to)2333-2344
Number of pages12
JournalQuality of Life Research
Issue number10
StatePublished - Oct 14 2015
Externally publishedYes


  • Oncology
  • Patient-reported outcomes
  • Physical function
  • Validation studies

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


Dive into the research topics of 'Validation of the PROMIS physical function measures in a diverse US population-based cohort of cancer patients'. Together they form a unique fingerprint.

Cite this