Abstract
Purpose: To evaluate the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) physical function measures in a diverse, population-based cancer sample. Methods: Cancer patients 6–13 months post-diagnosis (n = 4840) were recruited for the Measuring Your Health study. Participants were diagnosed between 2010 and 2013 with non-Hodgkin lymphoma or cancers of the colorectum, lung, breast, uterus, cervix, or prostate. Four PROMIS physical function short forms (4a, 6b, 10a, and 16) were evaluated for validity and reliability across age and race–ethnicity groups. Covariates included gender, marital status, education level, cancer site and stage, comorbidities, and functional status. Results: PROMIS physical function short forms showed high internal consistency (Cronbach’s α = 0.92–0.96), convergent validity (fatigue, pain interference, FACT physical well-being all r ≥ 0.68), and discriminant validity (unrelated domains all r ≤ 0.3) across survey short forms, age, and race–ethnicity. Known-group differences by demographic, clinical, and functional characteristics performed as hypothesized. Ceiling effects for higher-functioning individuals were identified on most forms. Conclusions: This study provides strong evidence that PROMIS physical function measures are valid and reliable in multiple race–ethnicity and age groups. Researchers selecting specific PROMIS short forms should consider the degree of functional disability in their patient population to ensure that length and content are tailored to limit response burden.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2333-2344 |
| Number of pages | 12 |
| Journal | Quality of Life Research |
| Volume | 24 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 14 2015 |
| Externally published | Yes |
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Keywords
- Oncology
- Patient-reported outcomes
- Physical function
- Validation studies
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
Cite this
Validation of the PROMIS physical function measures in a diverse US population-based cohort of cancer patients. / Jensen, Roxanne E.; Potosky, Arnold L.; Reeve, Bryce B.; Hahn, Elizabeth; Cella, David; Fries, James; Smith, Ashley Wilder; Keegan, Theresa H; Wu, Xiao Cheng; Paddock, Lisa; Moinpour, Carol M.
In: Quality of Life Research, Vol. 24, No. 10, 14.10.2015, p. 2333-2344.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Validation of the PROMIS physical function measures in a diverse US population-based cohort of cancer patients
AU - Jensen, Roxanne E.
AU - Potosky, Arnold L.
AU - Reeve, Bryce B.
AU - Hahn, Elizabeth
AU - Cella, David
AU - Fries, James
AU - Smith, Ashley Wilder
AU - Keegan, Theresa H
AU - Wu, Xiao Cheng
AU - Paddock, Lisa
AU - Moinpour, Carol M.
PY - 2015/10/14
Y1 - 2015/10/14
N2 - Purpose: To evaluate the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) physical function measures in a diverse, population-based cancer sample. Methods: Cancer patients 6–13 months post-diagnosis (n = 4840) were recruited for the Measuring Your Health study. Participants were diagnosed between 2010 and 2013 with non-Hodgkin lymphoma or cancers of the colorectum, lung, breast, uterus, cervix, or prostate. Four PROMIS physical function short forms (4a, 6b, 10a, and 16) were evaluated for validity and reliability across age and race–ethnicity groups. Covariates included gender, marital status, education level, cancer site and stage, comorbidities, and functional status. Results: PROMIS physical function short forms showed high internal consistency (Cronbach’s α = 0.92–0.96), convergent validity (fatigue, pain interference, FACT physical well-being all r ≥ 0.68), and discriminant validity (unrelated domains all r ≤ 0.3) across survey short forms, age, and race–ethnicity. Known-group differences by demographic, clinical, and functional characteristics performed as hypothesized. Ceiling effects for higher-functioning individuals were identified on most forms. Conclusions: This study provides strong evidence that PROMIS physical function measures are valid and reliable in multiple race–ethnicity and age groups. Researchers selecting specific PROMIS short forms should consider the degree of functional disability in their patient population to ensure that length and content are tailored to limit response burden.
AB - Purpose: To evaluate the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) physical function measures in a diverse, population-based cancer sample. Methods: Cancer patients 6–13 months post-diagnosis (n = 4840) were recruited for the Measuring Your Health study. Participants were diagnosed between 2010 and 2013 with non-Hodgkin lymphoma or cancers of the colorectum, lung, breast, uterus, cervix, or prostate. Four PROMIS physical function short forms (4a, 6b, 10a, and 16) were evaluated for validity and reliability across age and race–ethnicity groups. Covariates included gender, marital status, education level, cancer site and stage, comorbidities, and functional status. Results: PROMIS physical function short forms showed high internal consistency (Cronbach’s α = 0.92–0.96), convergent validity (fatigue, pain interference, FACT physical well-being all r ≥ 0.68), and discriminant validity (unrelated domains all r ≤ 0.3) across survey short forms, age, and race–ethnicity. Known-group differences by demographic, clinical, and functional characteristics performed as hypothesized. Ceiling effects for higher-functioning individuals were identified on most forms. Conclusions: This study provides strong evidence that PROMIS physical function measures are valid and reliable in multiple race–ethnicity and age groups. Researchers selecting specific PROMIS short forms should consider the degree of functional disability in their patient population to ensure that length and content are tailored to limit response burden.
KW - Oncology
KW - Patient-reported outcomes
KW - Physical function
KW - Validation studies
UR - http://www.scopus.com/inward/record.url?scp=84941417627&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941417627&partnerID=8YFLogxK
U2 - 10.1007/s11136-015-0992-9
DO - 10.1007/s11136-015-0992-9
M3 - Article
VL - 24
SP - 2333
EP - 2344
JO - Quality of Life Research
JF - Quality of Life Research
SN - 0962-9343
IS - 10
ER -