Vagus nerve stimulation in an adult male with fragile X syndrome

David R Hessl, Lesley J. Deprey, Roger L. Huff, Lorraine Ruiz, Randi J Hagerman

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


We present a case study of vagus nerve stimulation to treat epilepsy in an adult male with fragile X syndrome. This patient had seizures beginning at about two years of age. He did relatively well on anticonvulsant medications until reaching his thirties, when he experienced a resurgence of seizures, occurring about twice per week, and a decline in overall functioning. During one year of vagus nerve stimulation , he had a total of four to five seizures, his adaptive behavior and socialization improved, and he had reduced irritability and aggression. The possible benefits of vagus nerve stimulation in relation to what is known about brain morphology and function in fragile X is explored.

Original languageEnglish (US)
Pages (from-to)107-113
Number of pages7
JournalMental Health Aspects of Developmental Disabilities
Issue number3
StatePublished - Jul 2004


  • Aggression
  • Autism
  • Developmental
  • Epilepsy
  • FMR1 gene
  • Fragile X syndrome
  • Intellectual disability
  • Mental retardation
  • Mood
  • Psychiatric
  • Seizures
  • Stimulation
  • Vagus nerve stimulation

ASJC Scopus subject areas

  • Psychiatry and Mental health


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