Vaginal transmission of chimeric simian/human immunodeficiency viruses in rhesus macaques

Yichen Lu, Paul Brosio, Maria Lafaile, John Li, Ronald G. Collman, Joseph Sodroski, Chris J Miller

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Chimeric simian/human immunodeficiency viruses (SHIVs) that express the env genes derived from distinct HIV type 1 (HIV-1) isolates were tested for the ability to infect rhesus macaques following intravaginal inoculation. SHIVs containing either the HIV-1 HXBc2 or the HIV-1 89.6 envelope glycoproteins were capable of replicating in intravenously inoculated rhesus macaques. However, intravaginal inoculation of animals with these two SHIVs resulted in infection only with the SHIV containing the HIV-1 89.6 glycoprotein. Thus, properties conferred by the envelope glycoproteins in the chimeric virus affect the ability of particular SHIVs to initiate a systemic infection following vaginal inoculation. These results provide indirect support for the hypothesis that the selection of specific viral variants occurs in the genital tracts of individuals exposed to HIV by sexual contact.

Original languageEnglish (US)
Pages (from-to)3045-3050
Number of pages6
JournalJournal of Virology
Volume70
Issue number5
StatePublished - 1996

ASJC Scopus subject areas

  • Immunology

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    Lu, Y., Brosio, P., Lafaile, M., Li, J., Collman, R. G., Sodroski, J., & Miller, C. J. (1996). Vaginal transmission of chimeric simian/human immunodeficiency viruses in rhesus macaques. Journal of Virology, 70(5), 3045-3050.