Vagal afferents reflexly inhibit exercise in conscious rats

Chao-Yin Chen, H. L. Collins, C. Y. Chen

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Activation of vagal afferents reflexly inhibited locomotion induced by stimulation of the mesencephalic locomotor region in decerebrate cats. However, this reflex has not been tested in intact mammals. Therefore, the purpose of this study was to test the hypothesis that vagal afferent stimulation would inhibit somatomotor activity in the intact conscious rat. Six Sprague-Dawley rats were chronically instrumented with carotid arterial and femoral venous catheters and electromyogram (EMG) electrodes inserted into the biceps femoris muscle. Cardiac autonomic efferent blockade [atropine methyl bromide (14 mg · kg-1, i.v.) and metoprolol (14 mg · kg-1, i.v.)] and alpha-adrenergic receptor blockade [phenoxybenzamine (5 mg · kg- 1, i.v.)] was achieved to prevent bradycardia and hypotension. Vagal afferents were stimulated (phenylbiguanide 2.5 and 5.0 μg · kg-1 i.v.) during steady state exercise (9.0 m · min-1, 10% grade). Phenylbiguanide decreased exercise EMG activity 30 ± 6% and 54 ± 10% in a dose dependent manner without significantly altering mean arterial pressure or heart rate. We speculate that this reflex may serve as a negative feedback mechanism to indirectly reduce myocardial oxygen demands during exercise.

Original languageEnglish (US)
Pages (from-to)459-462
Number of pages4
JournalMedicine and Science in Sports and Exercise
Volume26
Issue number4
StatePublished - 1994
Externally publishedYes

Fingerprint

methyl bromide
Electromyography
Reflex
Adrenergic alpha-1 Receptors
Phenoxybenzamine
Metoprolol
Locomotion
Bradycardia
Thigh
Atropine
Hypotension
Sprague Dawley Rats
Mammals
Arterial Pressure
Electrodes
Cats
Catheters
Heart Rate
Oxygen
Muscles

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Vagal afferents reflexly inhibit exercise in conscious rats. / Chen, Chao-Yin; Collins, H. L.; Chen, C. Y.

In: Medicine and Science in Sports and Exercise, Vol. 26, No. 4, 1994, p. 459-462.

Research output: Contribution to journalArticle

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