Vagal afferent neurons in high fat diet-induced obesity; intestinal microflora, gut inflammation and cholecystokinin

Guillaume de Lartigue, Claire Barbier de La Serre, Helen E Raybould

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

The vagal afferent pathway is the major neural pathway by which information about ingested nutrients reaches the CNS and influences both GI function and feeding behavior. Vagal afferent neurons (VAN) express receptors for many of the regulatory peptides and molecules released from the intestinal wall, pancreas, and adipocytes that influence GI function, glucose homeostasis, and regulate food intake and body weight. As such, they play a critical role in both physiology and pathophysiology, such as obesity, where there is evidence that vagal afferent function is altered. This review will summarize recent findings on changes in vagal afferent function in response to ingestion of high fat diets and explore the hypothesis that changes in gut microbiota and integrity of the epithelium may not only be important in inducing these changes but may be the initial events that lead to dysregulation of food intake and body weight in response to high fat, high energy diets.

Original languageEnglish (US)
Pages (from-to)100-105
Number of pages6
JournalPhysiology and Behavior
Volume105
Issue number1
DOIs
StatePublished - Nov 30 2011

Keywords

  • Bacteroidales
  • CCK type 1 receptors
  • Closatridiales
  • Cocaine- and amphetamine-regulated peptide
  • EGR-1
  • Leptin
  • Lipopolysaccharide
  • Phosphorylated STAT3
  • Suppressor of cytokine signaling 3
  • TLR-4

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology
  • Philosophy

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