Vacuolar myopathy in a dog resembling human sporadic inclusion body myositis

Jason King, Richard A Lecouteur, Monica R Aleman, D. Colette Williams, Peter F Moore, Ling T. Guo, Andrew P. Mizisin, G. Diane Shelton

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Sporadic inclusion body myositis (sIBM) is the most common myopathy in people over the age of 50 years. While immune-mediated inflammatory myopathies are well documented in dogs, sIBM has not been described. An 11-year-old dog with chronic and progressive neuromuscular dysfunction was evaluated for evidence of sIBM using current pathologic, immunohistochemical and electron microscopic diagnostic criteria. Vacuoles and congophilic intracellular inclusions were identified in cryostat sections of multiple muscle biopsies and immunostained with antibodies against amyloid-β peptide, amyloid-β precursor protein, and proteosome 20S of the ubiquitin-proteosome system. Cellular infiltration and increased expression of MHC Class I antigen were observed. Cytoplasmic filamentous inclusions, membranous structures, and myeloid bodies were identified ultrastructurally. These observations constitute the first evidence that both the inflammatory and degenerative features of human sIBM can occur in a non-human species.

Original languageEnglish (US)
Pages (from-to)711-717
Number of pages7
JournalActa Neuropathologica
Volume118
Issue number5
DOIs
StatePublished - Nov 2009

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Keywords

  • Aging
  • Canine
  • Inflammatory
  • Muscle
  • Myopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Cellular and Molecular Neuroscience

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