Abstract
Vesicular stomatitis virus (VSV) causes a contagious disease of horses, cattle, and pigs. When DNA copies of messenger RNA's for the G or N proteins of VSV were linked to a vaccinia virus promoter and inserted into the vaccinia genome, the recombinants retained infectivity and synthesized VSV polypeptides. After intradermal vaccination with live recombinant virus expressing the G protein, mice produced VSV-neutralizing antibodies and were protected against lethal encephalitis upon intravenous challenge with VSV. In cattle, the degree of protection against intradermalingually injected VSV was correlated with the level of neutralizing antibody produced following vaccination.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 433-435 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 227 |
| Issue number | 4685 |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- General
Cite this
Vaccinia virus recombinants : Expression of VSV genes and protective immunization of mice and cattle. / Mackett, M.; Yilma, Tilahun; Rose, J. K.; Moss, B.
In: Science, Vol. 227, No. 4685, 1985, p. 433-435.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vaccinia virus recombinants
T2 - Expression of VSV genes and protective immunization of mice and cattle
AU - Mackett, M.
AU - Yilma, Tilahun
AU - Rose, J. K.
AU - Moss, B.
PY - 1985
Y1 - 1985
N2 - Vesicular stomatitis virus (VSV) causes a contagious disease of horses, cattle, and pigs. When DNA copies of messenger RNA's for the G or N proteins of VSV were linked to a vaccinia virus promoter and inserted into the vaccinia genome, the recombinants retained infectivity and synthesized VSV polypeptides. After intradermal vaccination with live recombinant virus expressing the G protein, mice produced VSV-neutralizing antibodies and were protected against lethal encephalitis upon intravenous challenge with VSV. In cattle, the degree of protection against intradermalingually injected VSV was correlated with the level of neutralizing antibody produced following vaccination.
AB - Vesicular stomatitis virus (VSV) causes a contagious disease of horses, cattle, and pigs. When DNA copies of messenger RNA's for the G or N proteins of VSV were linked to a vaccinia virus promoter and inserted into the vaccinia genome, the recombinants retained infectivity and synthesized VSV polypeptides. After intradermal vaccination with live recombinant virus expressing the G protein, mice produced VSV-neutralizing antibodies and were protected against lethal encephalitis upon intravenous challenge with VSV. In cattle, the degree of protection against intradermalingually injected VSV was correlated with the level of neutralizing antibody produced following vaccination.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021917922&partnerID=8YFLogxK
M3 - Article
C2 - 2981435
AN - SCOPUS:0021917922
VL - 227
SP - 433
EP - 435
JO - Science
JF - Science
SN - 0036-8075
IS - 4685
ER -