Vaccination of pregnant macaques protects newborns against mucosal simian immunodeficiency virus infection

Koen K.A. Van Rompay; Moses G. Otsyula; Ross P. Tarara; Don R. Canfield; Christopher J. Berardi; Michael B. McChesney; Marta Marthas

doi:10.1093/infdis/173.6.1327

Vaccination of pregnant macaques protects newborns against mucosal simian immunodeficiency virus infection

Koen K.A. Van Rompay, Moses G. Otsyula, Ross P. Tarara, Don R. Canfield, Christopher J. Berardi, Michael B. McChesney, Marta Marthas

School of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a rapid, sensitive animal model of human pediatric AIDS. Newborn macaques were readily infected by uncloned SIV(mac) following oral- conjunctival exposure and had persistently high viremia and rapid development of AIDS. In contrast, when 3 pregnant macaques were vaccinated against SIV, 2 of the newborns that had transplacentally acquired antiviral antibodies were protected against mucosal SIV infection at birth. These results suggest that intervention strategies such as active immunization of human immunodeficiency virus (HIV)-infected pregnant women and anti-HIV immunoglobulin administration may decrease the rate of perinatal HIV infection.

Original language	English (US)
Pages (from-to)	1327-1335
Number of pages	9
Journal	Journal of Infectious Diseases
Volume	173
Issue number	6
DOIs	https://doi.org/10.1093/infdis/173.6.1327
State	Published - Jan 1 1996

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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Vaccination of pregnant macaques protects newborns against mucosal simian immunodeficiency virus infection. / Van Rompay, Koen K.A.; Otsyula, Moses G.; Tarara, Ross P.; Canfield, Don R.; Berardi, Christopher J.; McChesney, Michael B.; Marthas, Marta.

In: Journal of Infectious Diseases, Vol. 173, No. 6, 01.01.1996, p. 1327-1335.

Research output: Contribution to journal › Article › peer-review

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abstract = "Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a rapid, sensitive animal model of human pediatric AIDS. Newborn macaques were readily infected by uncloned SIV(mac) following oral- conjunctival exposure and had persistently high viremia and rapid development of AIDS. In contrast, when 3 pregnant macaques were vaccinated against SIV, 2 of the newborns that had transplacentally acquired antiviral antibodies were protected against mucosal SIV infection at birth. These results suggest that intervention strategies such as active immunization of human immunodeficiency virus (HIV)-infected pregnant women and anti-HIV immunoglobulin administration may decrease the rate of perinatal HIV infection.",

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AB - Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a rapid, sensitive animal model of human pediatric AIDS. Newborn macaques were readily infected by uncloned SIV(mac) following oral- conjunctival exposure and had persistently high viremia and rapid development of AIDS. In contrast, when 3 pregnant macaques were vaccinated against SIV, 2 of the newborns that had transplacentally acquired antiviral antibodies were protected against mucosal SIV infection at birth. These results suggest that intervention strategies such as active immunization of human immunodeficiency virus (HIV)-infected pregnant women and anti-HIV immunoglobulin administration may decrease the rate of perinatal HIV infection.

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