Abstract
Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a rapid, sensitive animal model of human pediatric AIDS. Newborn macaques were readily infected by uncloned SIV(mac) following oral- conjunctival exposure and had persistently high viremia and rapid development of AIDS. In contrast, when 3 pregnant macaques were vaccinated against SIV, 2 of the newborns that had transplacentally acquired antiviral antibodies were protected against mucosal SIV infection at birth. These results suggest that intervention strategies such as active immunization of human immunodeficiency virus (HIV)-infected pregnant women and anti-HIV immunoglobulin administration may decrease the rate of perinatal HIV infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1327-1335 |
| Number of pages | 9 |
| Journal | Journal of Infectious Diseases |
| Volume | 173 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1996 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases
Cite this
Vaccination of pregnant macaques protects newborns against mucosal simian immunodeficiency virus infection. / Van Rompay, Koen K.A.; Otsyula, Moses G.; Tarara, Ross P.; Canfield, Don R.; Berardi, Christopher J.; McChesney, Michael B.; Marthas, Marta.
In: Journal of Infectious Diseases, Vol. 173, No. 6, 01.01.1996, p. 1327-1335.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vaccination of pregnant macaques protects newborns against mucosal simian immunodeficiency virus infection
AU - Van Rompay, Koen K.A.
AU - Otsyula, Moses G.
AU - Tarara, Ross P.
AU - Canfield, Don R.
AU - Berardi, Christopher J.
AU - McChesney, Michael B.
AU - Marthas, Marta
PY - 1996/1/1
Y1 - 1996/1/1
N2 - Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a rapid, sensitive animal model of human pediatric AIDS. Newborn macaques were readily infected by uncloned SIV(mac) following oral- conjunctival exposure and had persistently high viremia and rapid development of AIDS. In contrast, when 3 pregnant macaques were vaccinated against SIV, 2 of the newborns that had transplacentally acquired antiviral antibodies were protected against mucosal SIV infection at birth. These results suggest that intervention strategies such as active immunization of human immunodeficiency virus (HIV)-infected pregnant women and anti-HIV immunoglobulin administration may decrease the rate of perinatal HIV infection.
AB - Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a rapid, sensitive animal model of human pediatric AIDS. Newborn macaques were readily infected by uncloned SIV(mac) following oral- conjunctival exposure and had persistently high viremia and rapid development of AIDS. In contrast, when 3 pregnant macaques were vaccinated against SIV, 2 of the newborns that had transplacentally acquired antiviral antibodies were protected against mucosal SIV infection at birth. These results suggest that intervention strategies such as active immunization of human immunodeficiency virus (HIV)-infected pregnant women and anti-HIV immunoglobulin administration may decrease the rate of perinatal HIV infection.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029849736&partnerID=8YFLogxK
U2 - 10.1093/infdis/173.6.1327
DO - 10.1093/infdis/173.6.1327
M3 - Article
VL - 173
SP - 1327
EP - 1335
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 6
ER -