Vaccination-induced distemper in kinkajous.

K. R. Kazacos, H. L. Thacker, H L Shivaprasad, P. P. Burger

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Following vaccination for distemper, using a modified live-virus vaccine developed for dogs, 2 young kinkajous (Potos flavus) developed diarrhea, then central nervous system disease. Clinical signs included myoclonus, head trembling, loss of muscular coordination, and convulsions. One kinkajou gradually recovered; the other seemed to recover, then relapsed and was euthanatized. Microscopic lesions included those of interstitial pneumonia and enteritis and multifocal lymphocytic inflammation, gliosis, spongiosis, and swollen and degenerating axons in the cerebral, cerebellar, and brain stem white matter. Similar lesions were found at all caudally, as exemplified by complete destruction of the dorsal funiculi and dorsal horns of the gray matter of the upper sacral cord segments. Eosinophilic intranuclear inclusions were seen histologically in the glia in the spinal cord, midbrain, and cerebellum, and were confirmed as canine distemper viral inclusions by the fluorescent antibody method. It was concluded that modified live canine distemper virus vaccines should be used with caution or not at all in kinkajous.

Original languageEnglish (US)
Pages (from-to)1166-1169
Number of pages4
JournalJournal of the American Veterinary Medical Association
Issue number11
StatePublished - Dec 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)


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