Vaccination by inducing oral tolerance?

Immunological priming, protection and memory are the usual consequences of infection. However, in some instances, the host response might be inadequate or inappropriate, possibly as a result of strategies employed by the pathogen. Here, Stephen McSorley and Paul Garside discuss how oral tolerance protocols that have been employed recently in autoimmune disease models could be adapted specifically to prevent the development of inappropriate or pathological responses that occur during infection, thus functioning as effective vaccines.