Vaccination against Lyme disease caused by diverse Borrelia burgdorferi

Erol Fikrig, Sam R. Telford, Reinhard Wallich, Manchuan Chen, Yves Lobet, Franz R. Matuschka, Robert B. Kimsey, Fred S. Kantor, Stephen W Barthold, Andrew Spielman, Richard A. Flavell

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Diversity and mutations in the genes for outer surface proteins (Osps) A and B of Borrelia burgdorferi sensu lato (B. burgdorferi), the spirochetal agent of Lyme disease, suggests that a monovalent OspA or OspB vaccine may not provide protection against antigenically variable naturally occurring B burgdorferi. We now show that OspA or OspB immunizations protect mice from tick-borne infection with heterogeneous B. burgdorferi from different geographic regions. This result is in distinct contrast to in vitro killing analyses and in vivo protection studies using syringe injections of B. burgdorferi as the challenge inoculum. Evaluations of vaccine efficacy against Lyme disease and other vector-borne infections should use the natural mode of transmission and not be predicated on classification systems or assays that do not rely upon the vector to transmit infection.

Original languageEnglish (US)
Pages (from-to)215-221
Number of pages7
JournalJournal of Experimental Medicine
Volume181
Issue number1
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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    Fikrig, E., Telford, S. R., Wallich, R., Chen, M., Lobet, Y., Matuschka, F. R., Kimsey, R. B., Kantor, F. S., Barthold, S. W., Spielman, A., & Flavell, R. A. (1995). Vaccination against Lyme disease caused by diverse Borrelia burgdorferi. Journal of Experimental Medicine, 181(1), 215-221. https://doi.org/10.1084/jem.181.1.215