V600E BRAF mutation in pilocytic astrocytoma is associated with a more diffuse growth pattern but does not confer a more aggressive clinical behavior

Sergei I. Bannykh, James Mirocha, Miriam A Nuno, Jean Lopategui, Gokul Kandala

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Activation in mitogen activated protein kinase signaling pathway has recently been described as a predominant event in pilocytic astrocytoma (PA) and is commonly caused by constitutively active mutation in BRAF protein. Whereas PA of posterior fossa in children have a high prevalence of BRAF duplication and fusion, primary molecular abnormalities in supratentorial tumors of adults are more diverse and also include BRAF V600E point mutation. In our study we evaluated 51 PAs for BRAF duplication and BRAF V600E point mutation. We found a relatively high frequency of V600E mutation in our cohort. Histologically, V600E-carrying PA appeared more infiltrative, yet our limited clinical follow-up failed to detect a deleterious prognostic significance.

Original languageEnglish (US)
Pages (from-to)388-398
Number of pages11
JournalClinical Neuropathology
Volume33
Issue number6
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Astrocytoma
Point Mutation
Mutation
Growth
Supratentorial Neoplasms
Mutation Rate
Mitogen-Activated Protein Kinases
Proteins

Keywords

  • Astrocytoma
  • BRAF
  • Pilocytic
  • Prognosis
  • V600E

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology

Cite this

V600E BRAF mutation in pilocytic astrocytoma is associated with a more diffuse growth pattern but does not confer a more aggressive clinical behavior. / Bannykh, Sergei I.; Mirocha, James; Nuno, Miriam A; Lopategui, Jean; Kandala, Gokul.

In: Clinical Neuropathology, Vol. 33, No. 6, 01.01.2014, p. 388-398.

Research output: Contribution to journalArticle

@article{6dc6d4207231446bb7525f4a89023a31,
title = "V600E BRAF mutation in pilocytic astrocytoma is associated with a more diffuse growth pattern but does not confer a more aggressive clinical behavior",
abstract = "Activation in mitogen activated protein kinase signaling pathway has recently been described as a predominant event in pilocytic astrocytoma (PA) and is commonly caused by constitutively active mutation in BRAF protein. Whereas PA of posterior fossa in children have a high prevalence of BRAF duplication and fusion, primary molecular abnormalities in supratentorial tumors of adults are more diverse and also include BRAF V600E point mutation. In our study we evaluated 51 PAs for BRAF duplication and BRAF V600E point mutation. We found a relatively high frequency of V600E mutation in our cohort. Histologically, V600E-carrying PA appeared more infiltrative, yet our limited clinical follow-up failed to detect a deleterious prognostic significance.",
keywords = "Astrocytoma, BRAF, Pilocytic, Prognosis, V600E",
author = "Bannykh, {Sergei I.} and James Mirocha and Nuno, {Miriam A} and Jean Lopategui and Gokul Kandala",
year = "2014",
month = "1",
day = "1",
doi = "10.5414/NP300753",
language = "English (US)",
volume = "33",
pages = "388--398",
journal = "Clinical Neuropathology",
issn = "0722-5091",
publisher = "Dustri-Verlag Dr. Karl Feistle",
number = "6",

}

TY - JOUR

T1 - V600E BRAF mutation in pilocytic astrocytoma is associated with a more diffuse growth pattern but does not confer a more aggressive clinical behavior

AU - Bannykh, Sergei I.

AU - Mirocha, James

AU - Nuno, Miriam A

AU - Lopategui, Jean

AU - Kandala, Gokul

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Activation in mitogen activated protein kinase signaling pathway has recently been described as a predominant event in pilocytic astrocytoma (PA) and is commonly caused by constitutively active mutation in BRAF protein. Whereas PA of posterior fossa in children have a high prevalence of BRAF duplication and fusion, primary molecular abnormalities in supratentorial tumors of adults are more diverse and also include BRAF V600E point mutation. In our study we evaluated 51 PAs for BRAF duplication and BRAF V600E point mutation. We found a relatively high frequency of V600E mutation in our cohort. Histologically, V600E-carrying PA appeared more infiltrative, yet our limited clinical follow-up failed to detect a deleterious prognostic significance.

AB - Activation in mitogen activated protein kinase signaling pathway has recently been described as a predominant event in pilocytic astrocytoma (PA) and is commonly caused by constitutively active mutation in BRAF protein. Whereas PA of posterior fossa in children have a high prevalence of BRAF duplication and fusion, primary molecular abnormalities in supratentorial tumors of adults are more diverse and also include BRAF V600E point mutation. In our study we evaluated 51 PAs for BRAF duplication and BRAF V600E point mutation. We found a relatively high frequency of V600E mutation in our cohort. Histologically, V600E-carrying PA appeared more infiltrative, yet our limited clinical follow-up failed to detect a deleterious prognostic significance.

KW - Astrocytoma

KW - BRAF

KW - Pilocytic

KW - Prognosis

KW - V600E

UR - http://www.scopus.com/inward/record.url?scp=84930386971&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930386971&partnerID=8YFLogxK

U2 - 10.5414/NP300753

DO - 10.5414/NP300753

M3 - Article

VL - 33

SP - 388

EP - 398

JO - Clinical Neuropathology

JF - Clinical Neuropathology

SN - 0722-5091

IS - 6

ER -