V-erbA and c-erbA proteins enhance transcriptional activation by c-jun

Mohammed Sharif, Martin L. Privalsky

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The ability of different transcription factors to interact with one another is an important means by which the eucaryotic cell can integrate separate growth and differentiation signals into a coherent response. We report here an analysis of the interactions of transcription factors that are also the products of oncogenes: the erbA, jun and fos proteins. We demonstrate that the c-jun polypeptide can functionally interact with the c-erbA protein (thyroid hormone receptor) to yield an enhanced activity greater than that of either factor individually. Although the avian erythroblastosis v-erbA allele is generally thought to act as a transcriptional repressor in vertebrate cells, we also report the existence of promoter contexts where v-erbA, as well as c-erbA, can serve as 'co-activators' of c-jun function. V-erbA appears to augment retinoic acid receptor function in the same context. Our results suggest that v-erbA may have unanticipated positive effect on transcription in the neoplastic cell in addition to the repressor functions previously characterized.

Original languageEnglish (US)
Pages (from-to)953-960
Number of pages8
JournalOncogene
Volume7
Issue number5
StatePublished - May 1992

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

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    Sharif, M., & Privalsky, M. L. (1992). V-erbA and c-erbA proteins enhance transcriptional activation by c-jun. Oncogene, 7(5), 953-960.