Uveodermatologic (VKH-like) syndrome in American Akita dogs is associated with an increased frequency of DQA1*00201

J. M. Angles, T. R. Famula, Niels C Pedersen

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The Akita breed of dog is affected by a number of distinct immune-mediated diseases, including thyroiditis, sebaceous adenitis, pemphigus foliaceus, uveitis, polyarthritis, myasthenia gravis, and uveodermatologic (UV) syndrome. UV syndrome is manifested by progressive uveitis and depigmenting dermatitis that closely resembles the human Vogt - Koyanagi - Harada syndrome. This study examined the allelic diversity of the three DLA class II loci (DRB1, DQA1, and DQB1) in the American Akita dog, and the relationship of specific DLA class II alleles to the UV. Low allelic variation was demonstrated within genes of DLA class II. American Akita dogs possessed six of the reported 16 DQA1 alleles, but only eight of 61 reported alleles in DRB1 and nine of 47 reported alleles in DQB1. Almost one-half of American Akita dogs were homozygous for a single allele at DQA1 and up to a quarter at DRB1 and DQB1. DLA-DQA1*00201 was associated with a significantly higher relative risk (RR = 15.3) or odds ratio (OR = 15.99) for UV syndrome than other DLA class II alleles. No significant association was noted with haplotypes of DRB1, DQB1, and DQA1 alleles; DRB1*03201-DQA1*00201 trended toward significance. This study confirmed loss of DLA genetic diversity in the American Akita dog in common with other pure breeds of dog and suggested a role for certain DLA class II gene alleles in the pathogenesis of UV.

Original languageEnglish (US)
Pages (from-to)656-665
Number of pages10
JournalTissue Antigens
Volume66
Issue number6
DOIs
StatePublished - Dec 2005

Fingerprint

Uveomeningoencephalitic Syndrome
Alleles
Dogs
MHC Class II Genes
Uveitis
Thyroiditis
Lymphadenitis
Pemphigus
Myasthenia Gravis
Immune System Diseases
Dermatitis
Haplotypes
Arthritis
Odds Ratio

Keywords

  • Canine
  • DLA-DQA1
  • DLA-DQB1
  • DLA-DRB1
  • Uveodermatologic syndrome
  • VKH-like

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Uveodermatologic (VKH-like) syndrome in American Akita dogs is associated with an increased frequency of DQA1*00201. / Angles, J. M.; Famula, T. R.; Pedersen, Niels C.

In: Tissue Antigens, Vol. 66, No. 6, 12.2005, p. 656-665.

Research output: Contribution to journalArticle

@article{63c7c004405f4e94805c5b5149123e19,
title = "Uveodermatologic (VKH-like) syndrome in American Akita dogs is associated with an increased frequency of DQA1*00201",
abstract = "The Akita breed of dog is affected by a number of distinct immune-mediated diseases, including thyroiditis, sebaceous adenitis, pemphigus foliaceus, uveitis, polyarthritis, myasthenia gravis, and uveodermatologic (UV) syndrome. UV syndrome is manifested by progressive uveitis and depigmenting dermatitis that closely resembles the human Vogt - Koyanagi - Harada syndrome. This study examined the allelic diversity of the three DLA class II loci (DRB1, DQA1, and DQB1) in the American Akita dog, and the relationship of specific DLA class II alleles to the UV. Low allelic variation was demonstrated within genes of DLA class II. American Akita dogs possessed six of the reported 16 DQA1 alleles, but only eight of 61 reported alleles in DRB1 and nine of 47 reported alleles in DQB1. Almost one-half of American Akita dogs were homozygous for a single allele at DQA1 and up to a quarter at DRB1 and DQB1. DLA-DQA1*00201 was associated with a significantly higher relative risk (RR = 15.3) or odds ratio (OR = 15.99) for UV syndrome than other DLA class II alleles. No significant association was noted with haplotypes of DRB1, DQB1, and DQA1 alleles; DRB1*03201-DQA1*00201 trended toward significance. This study confirmed loss of DLA genetic diversity in the American Akita dog in common with other pure breeds of dog and suggested a role for certain DLA class II gene alleles in the pathogenesis of UV.",
keywords = "Canine, DLA-DQA1, DLA-DQB1, DLA-DRB1, Uveodermatologic syndrome, VKH-like",
author = "Angles, {J. M.} and Famula, {T. R.} and Pedersen, {Niels C}",
year = "2005",
month = "12",
doi = "10.1111/j.1399-0039.2005.00508.x",
language = "English (US)",
volume = "66",
pages = "656--665",
journal = "HLA",
issn = "2059-2302",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Uveodermatologic (VKH-like) syndrome in American Akita dogs is associated with an increased frequency of DQA1*00201

AU - Angles, J. M.

AU - Famula, T. R.

AU - Pedersen, Niels C

PY - 2005/12

Y1 - 2005/12

N2 - The Akita breed of dog is affected by a number of distinct immune-mediated diseases, including thyroiditis, sebaceous adenitis, pemphigus foliaceus, uveitis, polyarthritis, myasthenia gravis, and uveodermatologic (UV) syndrome. UV syndrome is manifested by progressive uveitis and depigmenting dermatitis that closely resembles the human Vogt - Koyanagi - Harada syndrome. This study examined the allelic diversity of the three DLA class II loci (DRB1, DQA1, and DQB1) in the American Akita dog, and the relationship of specific DLA class II alleles to the UV. Low allelic variation was demonstrated within genes of DLA class II. American Akita dogs possessed six of the reported 16 DQA1 alleles, but only eight of 61 reported alleles in DRB1 and nine of 47 reported alleles in DQB1. Almost one-half of American Akita dogs were homozygous for a single allele at DQA1 and up to a quarter at DRB1 and DQB1. DLA-DQA1*00201 was associated with a significantly higher relative risk (RR = 15.3) or odds ratio (OR = 15.99) for UV syndrome than other DLA class II alleles. No significant association was noted with haplotypes of DRB1, DQB1, and DQA1 alleles; DRB1*03201-DQA1*00201 trended toward significance. This study confirmed loss of DLA genetic diversity in the American Akita dog in common with other pure breeds of dog and suggested a role for certain DLA class II gene alleles in the pathogenesis of UV.

AB - The Akita breed of dog is affected by a number of distinct immune-mediated diseases, including thyroiditis, sebaceous adenitis, pemphigus foliaceus, uveitis, polyarthritis, myasthenia gravis, and uveodermatologic (UV) syndrome. UV syndrome is manifested by progressive uveitis and depigmenting dermatitis that closely resembles the human Vogt - Koyanagi - Harada syndrome. This study examined the allelic diversity of the three DLA class II loci (DRB1, DQA1, and DQB1) in the American Akita dog, and the relationship of specific DLA class II alleles to the UV. Low allelic variation was demonstrated within genes of DLA class II. American Akita dogs possessed six of the reported 16 DQA1 alleles, but only eight of 61 reported alleles in DRB1 and nine of 47 reported alleles in DQB1. Almost one-half of American Akita dogs were homozygous for a single allele at DQA1 and up to a quarter at DRB1 and DQB1. DLA-DQA1*00201 was associated with a significantly higher relative risk (RR = 15.3) or odds ratio (OR = 15.99) for UV syndrome than other DLA class II alleles. No significant association was noted with haplotypes of DRB1, DQB1, and DQA1 alleles; DRB1*03201-DQA1*00201 trended toward significance. This study confirmed loss of DLA genetic diversity in the American Akita dog in common with other pure breeds of dog and suggested a role for certain DLA class II gene alleles in the pathogenesis of UV.

KW - Canine

KW - DLA-DQA1

KW - DLA-DQB1

KW - DLA-DRB1

KW - Uveodermatologic syndrome

KW - VKH-like

UR - http://www.scopus.com/inward/record.url?scp=27944475581&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27944475581&partnerID=8YFLogxK

U2 - 10.1111/j.1399-0039.2005.00508.x

DO - 10.1111/j.1399-0039.2005.00508.x

M3 - Article

C2 - 16305682

AN - SCOPUS:27944475581

VL - 66

SP - 656

EP - 665

JO - HLA

JF - HLA

SN - 2059-2302

IS - 6

ER -