Utilizing small nutrient compounds as enhancers of exercise-induced mitochondrial biogenesis

Daniel M. Craig, Stephen P. Ashcroft, Micah Y. Belew, Ben Stocks, Kevin Currell, Keith Baar, Andrew Philp

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Endurance exercise, when performed regularly as part of a training program, leads to increases in whole-body and skeletal muscle-specific oxidative capacity. At the cellular level, this adaptive response is manifested by an increased number of oxidative fibers (Type I and IIA myosin heavy chain), an increase in capillarity and an increase in mitochondrial biogenesis. The increase in mitochondrial biogenesis (increased volume and functional capacity) is fundamentally important as it leads to greater rates of oxidative phosphorylation and an improved capacity to utilize fatty acids during sub-maximal exercise. Given the importance of mitochondrial biogenesis for skeletal muscle performance, considerable attention has been given to understanding the molecular cues stimulated by endurance exercise that culminate in this adaptive response. In turn, this research has led to the identification of pharmaceutical compounds and small nutritional bioactive ingredients that appear able to amplify exercise-responsive signaling pathways in skeletal muscle. The aim of this review is to discuss these purported exercise mimetics and bioactive ingredients in the context of mitochondrial biogenesis in skeletal muscle. We will examine proposed modes of action, discuss evidence of application in skeletal muscle in vivo and finally comment on the feasibility of such approaches to support endurance-training applications in humans.

Original languageEnglish (US)
Article number296
JournalFrontiers in Physiology
Volume6
Issue numberOCT
DOIs
StatePublished - 2015

Fingerprint

Organelle Biogenesis
Skeletal Muscle
Food
Capillary Action
Training Support
Myosin Heavy Chains
Oxidative Phosphorylation
Cues
Fatty Acids
Education
Research
Pharmaceutical Preparations

Keywords

  • Bioactives
  • Exercise mimetics
  • Mitochondrial biogenesis
  • Nutraceuticals
  • Skeletal muscle

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Craig, D. M., Ashcroft, S. P., Belew, M. Y., Stocks, B., Currell, K., Baar, K., & Philp, A. (2015). Utilizing small nutrient compounds as enhancers of exercise-induced mitochondrial biogenesis. Frontiers in Physiology, 6(OCT), [296]. https://doi.org/10.3389/fphys.2015.00296

Utilizing small nutrient compounds as enhancers of exercise-induced mitochondrial biogenesis. / Craig, Daniel M.; Ashcroft, Stephen P.; Belew, Micah Y.; Stocks, Ben; Currell, Kevin; Baar, Keith; Philp, Andrew.

In: Frontiers in Physiology, Vol. 6, No. OCT, 296, 2015.

Research output: Contribution to journalArticle

Craig, DM, Ashcroft, SP, Belew, MY, Stocks, B, Currell, K, Baar, K & Philp, A 2015, 'Utilizing small nutrient compounds as enhancers of exercise-induced mitochondrial biogenesis', Frontiers in Physiology, vol. 6, no. OCT, 296. https://doi.org/10.3389/fphys.2015.00296
Craig, Daniel M. ; Ashcroft, Stephen P. ; Belew, Micah Y. ; Stocks, Ben ; Currell, Kevin ; Baar, Keith ; Philp, Andrew. / Utilizing small nutrient compounds as enhancers of exercise-induced mitochondrial biogenesis. In: Frontiers in Physiology. 2015 ; Vol. 6, No. OCT.
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