Utilization of lymphoblastoid cell lines as a system for the molecular modeling of autism

Colin A. Baron, Stephenie Y. Liu, Chindo Hicks, Jeffrey Gregg

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

In order to provide an alternative approach for understanding the biology and genetics of autism, we performed statistical analysis of gene expression profiles of lymphoblastoid cell lines derived from children with autism and their families. The goal was to assess the feasibility of using this model in identifying autism-associated genes. Replicate microarray experiments demonstrated that expression data from the cell lines were consistent and highly reproducible. Further analyses identified differentially expressed genes between cell lines derived from children with autism and those derived from their normally developing siblings. These genes were then used to identify biochemical pathways potentially involved in autism. This study suggests that lymphoblastoid cell lines may be a viable tool for identifying genes associated with autism.

Original languageEnglish (US)
Pages (from-to)973-982
Number of pages10
JournalJournal of Autism and Developmental Disorders
Volume36
Issue number8
DOIs
StatePublished - Nov 2006

Keywords

  • Autism
  • Blood genomics
  • Gene expression
  • Lymphoblastoid cell lines
  • Microarray
  • PathwayAssist

ASJC Scopus subject areas

  • Psychology(all)
  • Developmental and Educational Psychology

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