Utilization of biocompatible ferrous particles for a new cancer therapy

Cahit A. Evrensel, Lisbeth A. Welniak, Alan Fuchs, Jigar Patel, William J Murphy, Faramarz Gordaninejad

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Magneto-rheologiacal Fluid (MRF), suspensions of polarizable micron size particles, is synthesized from suspensions of iron particles (micron and nano size) in phosphate buffered saline (PBS). The iron particles have been surface coated using atom transfer radical polymerization (ATRP) with various polymers, such as poly(N-isopropylacrylamide) (poly(NIPAAm)), and poly(acrylamide) (poly(AAm)). The surface grafted polymer has been characterized using differential scanning calorimetry (DSC), and properties of resulting fluid have been measured using a rheometer. A mathematical model is developed to explore the force induced by the particles on the neighboring tissue under externally applied magnetic field. This force results in the damage of the tumor cell lines and trigger the immune system response. The effect of MRF on primary and metastasized tumor growth were evaluated by using an orthotopic murine breast cancer model (4T1). Tumors were evaluated by growth measurements and histological changes following injection of MRF or carrier fluid alone into the tumor and the effects of subsequent application of a magnetic field to the site. Results indicate slowed tumor growth and increased dendritic cell activation with this therapy and they are encouraging.

Original languageEnglish (US)
Title of host publicationProceedings of the ASME Summer Bioengineering Conference 2009, SBC2009
Pages565-566
Number of pages2
EditionPART A
DOIs
StatePublished - 2009
Event11th ASME Summer Bioengineering Conference, SBC2009 - Lake Tahoe, CA, United States
Duration: Jun 17 2009Jun 21 2009

Other

Other11th ASME Summer Bioengineering Conference, SBC2009
Country/TerritoryUnited States
CityLake Tahoe, CA
Period6/17/096/21/09

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

Fingerprint

Dive into the research topics of 'Utilization of biocompatible ferrous particles for a new cancer therapy'. Together they form a unique fingerprint.

Cite this