Abstract
Magneto-rheologiacal Fluid (MRF), suspensions of polarizable micron size particles, is synthesized from suspensions of iron particles (micron and nano size) in phosphate buffered saline (PBS). The iron particles have been surface coated using atom transfer radical polymerization (ATRP) with various polymers, such as poly(N-isopropylacrylamide) (poly(NIPAAm)), and poly(acrylamide) (poly(AAm)). The surface grafted polymer has been characterized using differential scanning calorimetry (DSC), and properties of resulting fluid have been measured using a rheometer. A mathematical model is developed to explore the force induced by the particles on the neighboring tissue under externally applied magnetic field. This force results in the damage of the tumor cell lines and trigger the immune system response. The effect of MRF on primary and metastasized tumor growth were evaluated by using an orthotopic murine breast cancer model (4T1). Tumors were evaluated by growth measurements and histological changes following injection of MRF or carrier fluid alone into the tumor and the effects of subsequent application of a magnetic field to the site. Results indicate slowed tumor growth and increased dendritic cell activation with this therapy and they are encouraging.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009 |
| Pages | 565-566 |
| Number of pages | 2 |
| Edition | PART A |
| DOIs | |
| State | Published - 2009 |
| Event | 11th ASME Summer Bioengineering Conference, SBC2009 - Lake Tahoe, CA, United States Duration: Jun 17 2009 → Jun 21 2009 |
Other
| Other | 11th ASME Summer Bioengineering Conference, SBC2009 |
|---|---|
| Country | United States |
| City | Lake Tahoe, CA |
| Period | 6/17/09 → 6/21/09 |
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ASJC Scopus subject areas
- Biotechnology
- Bioengineering
Cite this
Utilization of biocompatible ferrous particles for a new cancer therapy. / Evrensel, Cahit A.; Welniak, Lisbeth A.; Fuchs, Alan; Patel, Jigar; Murphy, William J; Gordaninejad, Faramarz.
Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009. PART A. ed. 2009. p. 565-566.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Utilization of biocompatible ferrous particles for a new cancer therapy
AU - Evrensel, Cahit A.
AU - Welniak, Lisbeth A.
AU - Fuchs, Alan
AU - Patel, Jigar
AU - Murphy, William J
AU - Gordaninejad, Faramarz
PY - 2009
Y1 - 2009
N2 - Magneto-rheologiacal Fluid (MRF), suspensions of polarizable micron size particles, is synthesized from suspensions of iron particles (micron and nano size) in phosphate buffered saline (PBS). The iron particles have been surface coated using atom transfer radical polymerization (ATRP) with various polymers, such as poly(N-isopropylacrylamide) (poly(NIPAAm)), and poly(acrylamide) (poly(AAm)). The surface grafted polymer has been characterized using differential scanning calorimetry (DSC), and properties of resulting fluid have been measured using a rheometer. A mathematical model is developed to explore the force induced by the particles on the neighboring tissue under externally applied magnetic field. This force results in the damage of the tumor cell lines and trigger the immune system response. The effect of MRF on primary and metastasized tumor growth were evaluated by using an orthotopic murine breast cancer model (4T1). Tumors were evaluated by growth measurements and histological changes following injection of MRF or carrier fluid alone into the tumor and the effects of subsequent application of a magnetic field to the site. Results indicate slowed tumor growth and increased dendritic cell activation with this therapy and they are encouraging.
AB - Magneto-rheologiacal Fluid (MRF), suspensions of polarizable micron size particles, is synthesized from suspensions of iron particles (micron and nano size) in phosphate buffered saline (PBS). The iron particles have been surface coated using atom transfer radical polymerization (ATRP) with various polymers, such as poly(N-isopropylacrylamide) (poly(NIPAAm)), and poly(acrylamide) (poly(AAm)). The surface grafted polymer has been characterized using differential scanning calorimetry (DSC), and properties of resulting fluid have been measured using a rheometer. A mathematical model is developed to explore the force induced by the particles on the neighboring tissue under externally applied magnetic field. This force results in the damage of the tumor cell lines and trigger the immune system response. The effect of MRF on primary and metastasized tumor growth were evaluated by using an orthotopic murine breast cancer model (4T1). Tumors were evaluated by growth measurements and histological changes following injection of MRF or carrier fluid alone into the tumor and the effects of subsequent application of a magnetic field to the site. Results indicate slowed tumor growth and increased dendritic cell activation with this therapy and they are encouraging.
UR - http://www.scopus.com/inward/record.url?scp=77953955924&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953955924&partnerID=8YFLogxK
U2 - 10.1115/SBC2009-206803
DO - 10.1115/SBC2009-206803
M3 - Conference contribution
AN - SCOPUS:77953955924
SN - 9780791848913
SP - 565
EP - 566
BT - Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009
ER -