Utilization and impact of a postmastectomy radiation boost for invasive breast cancer

Jyoti Mayadev, Kari Fish, Richard K Valicenti, Dee West, Allen Chen, Steven Martinez, Theodore Phillips

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Additional radiation following postmastectomy radiation (PMRT) has an undefined benefit. We investigate those likely to be selected for a chest wall boost (CWB) and its effect on breast cancer survival (BCS) and overall survival (OS). Methods and materials: A total of 4747 women diagnosed from 2005 to 2009 were treated with PMRT identified from the California Cancer Registry (CCR); 2686 (57%) received a CWB. Univariate and multivariate analyses compared those receiving and not receiving a CWB for BCS and OS. Results: With a median follow-up of 43.6 months, patients likely to receive a CWB were stage III (. P ≤ .001), grade 3/4 (. P = .03), positive nodes (. P = .04), HER 2. + (. P =. .02). CWB was not related to BCS in the univariate (hazard ratio [HR], 1.00; 95% confidence interval [CI], 0.82-1.21), multivariate (HR, 1.04; 95% CI, 0.86 -1.26) analyses, and was not related OS for the univariate (HR, 0.92; 95% CI, 0.78-1.10), multivariate (HR, 0.95; 95% CI, 0.80-1.13) analyses. However, in multivariate analysis, patients not receiving chemotherapy who had a CWB had better BCS (HR, 1.77; 95% CI, 1.11-2.83). Conclusions: The majority of patients were treated with a CWB. We found no difference in BCS or OS with the addition of a CWB.

Original languageEnglish (US)
Pages (from-to)E269-E278
JournalPractical Radiation Oncology
Volume4
Issue number6
DOIs
StatePublished - Nov 1 2014

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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