Utility of stress echocardiography in identifying significant coronary artery disease in patients with left bundle-branch block

William R Lewis, Rick Ganim, Rajendran Sabapathy

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

HYPOTHESIS: The aim of the study was to determine the utility of stress echocardiography for identification of significant coronary artery disease (CAD) in higher-risk patients with an underlying left bundle-branch block (LBBB). METHODS: Patients with LBBB undergoing stress echocardiography were divided into 2 groups: group 1 (no history MI), group 2 (history MI). Positive stress echocardiograms were compared with the presence of >50% luminal-diameter stenosis during coronary angiography. During the follow-up (FU) period, cardiac events were determined for hard and soft endpoints. RESULTS: Sixty consecutive patients with LBBB underwent stress echocardiography. Twenty-eight patients had a positive stress echocardiogram (20 group 1; 8 group 2). Nineteen of these patients underwent coronary angiography (14 group 1; 5 group 2). In group 1, regional wall motion abnormality (RWMA) correlated with coronary anatomy in only 5 patients, while in group 2, RWMA correlated with coronary anatomy in only 2 patients. There were 12 false positives, with echocardiographic abnormalities identified. The positive predictive values in groups 1 and 2 were 35.7% and 40%, respectively. During the FU period, there was 1 mortality, 2 MI, 2 coronary revascularizations, and 6 hospitalizations (2 chest pain, 1 CHF, 3 coronary angiography). The negative predictive value for hard endpoints was 83%. CONCLUSION: Stress echocardiography has a poor positive predictive value to identify significant angiographic CAD in higher-risk patients with LBBB; however, the negative predictive value for hard ischemic events is similar to patients without LBBB.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalCritical Pathways in Cardiology
Volume6
Issue number3
DOIs
StatePublished - Sep 2007

Keywords

  • Coronary artery disease
  • Left bundle-branch block
  • Stress echocardiography

ASJC Scopus subject areas

  • Medicine(all)

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