Utility of daily image guidance with intensity-modulated radiotherapy for tumors of the base of skull

Allen M. Chen, Suzan Cheng, D Gregory Farwell, Quang Luu, Paul J. Donald, James E Boggan, Stephen Franklin, James A. Purdy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background This study was carried out to report our experience using intensity-modulated radiotherapy (IMRT) with daily image-guided radiotherapy (IGRT) for tumors involving the base of skull. Methods In all, 100 patients were prospectively treated with IMRT to a median dose of 64 Gy (range, 45-70 Gy). Daily helical megavoltage computed tomography (MVCT) scans were obtained as part of an IGRT registration protocol for patient alignment. Results The 2-year local-regional control was 91%. A total of 3295 daily MVCT scans were obtained. The mean shift to account for interfraction motion was 1.18 ± 1.75 mm, 1.81 ± 1.34 mm, and 1.33 ± 1.19 mm for the medial-lateral (ML), superior-inferior (SI), and anterior-posterior (AP) directions, respectively. Pretreatment shifts of >3 mm occurred in 10%, 26%, and 18%, in the ML, SI, and AP directions, respectively. Conclusions The feasibility and efficacy of daily IGRT as a complement to IMRT for skull base were demonstrated.

Original languageEnglish (US)
Pages (from-to)763-770
Number of pages8
JournalHead and Neck
Volume34
Issue number6
DOIs
StatePublished - Jun 2012

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Image-Guided Radiotherapy
Intensity-Modulated Radiotherapy
Skull Base
Neoplasms
Spiral Computed Tomography
Tomography
Direction compound

Keywords

  • head and neck cancer
  • image-guided radiotherapy
  • intensity-modulated radiotherapy
  • on-board imaging
  • skull base

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Utility of daily image guidance with intensity-modulated radiotherapy for tumors of the base of skull. / Chen, Allen M.; Cheng, Suzan; Farwell, D Gregory; Luu, Quang; Donald, Paul J.; Boggan, James E; Franklin, Stephen; Purdy, James A.

In: Head and Neck, Vol. 34, No. 6, 06.2012, p. 763-770.

Research output: Contribution to journalArticle

Chen, Allen M. ; Cheng, Suzan ; Farwell, D Gregory ; Luu, Quang ; Donald, Paul J. ; Boggan, James E ; Franklin, Stephen ; Purdy, James A. / Utility of daily image guidance with intensity-modulated radiotherapy for tumors of the base of skull. In: Head and Neck. 2012 ; Vol. 34, No. 6. pp. 763-770.
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