Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD

H. J. Rosen, K. M. Hartikainen, W. Jagust, J. H. Kramer, Bruce R Reed, J. L. Cummings, K. Boone, W. Ellis, C. Miller, B. L. Miller

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

Objective: To assess the ability of the current diagnostic criteria for frontotemporal lobar degeneration (FTLD) to differentiate FTLD from AD. Methods: Thirty cases with autopsy-proven FTLD and 30 cases of AD, matched for Mini-Mental State Examination score, were identified from the clinical databases of three dementia subspecialty centers, and their charts were reviewed for the presence of clinical features described in the current criteria for FTLD. The proportion of patients with each clinical feature at the first clinical presentation was compared across groups. Results: A significantly larger proportion of patients with FTLD showed behavioral abnormalities, particularly social and personal conduct disorders and emotional blunting, than patients with AD. Few differences in language features were seen between the groups, and many of the language features detailed in the criteria were found in only a small proportion of patients. In both groups, many patients showed neuropsychological abnormalities, except for perceptual difficulties, which were present in many patients with AD but only in a few patients with FTLD. Extrapyramidal motor symptoms were more likely to be present in FTLD. Logistic regression revealed that five features-social conduct disorders, hyperorality, akinesia, absence of amnesia, and the absence of a perceptual disorder-correctly classified 93% of patients with FTLD and 97% of patients with AD. Conclusion: A combination of behavioral, neuropsychological, and physical findings is most useful in distinguishing FTLD from AD. Future studies should be directed at establishing more objective methods of identifying these clinical features.

Original languageEnglish (US)
Pages (from-to)1608-1615
Number of pages8
JournalNeurology
Volume58
Issue number11
StatePublished - Jun 11 2002

Fingerprint

Frontotemporal Lobar Degeneration
Conduct Disorder
Language
Perceptual Disorders
Aptitude
Amnesia
Dementia
Autopsy
Logistic Models
Databases

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Rosen, H. J., Hartikainen, K. M., Jagust, W., Kramer, J. H., Reed, B. R., Cummings, J. L., ... Miller, B. L. (2002). Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD. Neurology, 58(11), 1608-1615.

Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD. / Rosen, H. J.; Hartikainen, K. M.; Jagust, W.; Kramer, J. H.; Reed, Bruce R; Cummings, J. L.; Boone, K.; Ellis, W.; Miller, C.; Miller, B. L.

In: Neurology, Vol. 58, No. 11, 11.06.2002, p. 1608-1615.

Research output: Contribution to journalArticle

Rosen, HJ, Hartikainen, KM, Jagust, W, Kramer, JH, Reed, BR, Cummings, JL, Boone, K, Ellis, W, Miller, C & Miller, BL 2002, 'Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD', Neurology, vol. 58, no. 11, pp. 1608-1615.
Rosen HJ, Hartikainen KM, Jagust W, Kramer JH, Reed BR, Cummings JL et al. Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD. Neurology. 2002 Jun 11;58(11):1608-1615.
Rosen, H. J. ; Hartikainen, K. M. ; Jagust, W. ; Kramer, J. H. ; Reed, Bruce R ; Cummings, J. L. ; Boone, K. ; Ellis, W. ; Miller, C. ; Miller, B. L. / Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD. In: Neurology. 2002 ; Vol. 58, No. 11. pp. 1608-1615.
@article{c3c20ccb26394bff8682c2373e5f2e37,
title = "Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD",
abstract = "Objective: To assess the ability of the current diagnostic criteria for frontotemporal lobar degeneration (FTLD) to differentiate FTLD from AD. Methods: Thirty cases with autopsy-proven FTLD and 30 cases of AD, matched for Mini-Mental State Examination score, were identified from the clinical databases of three dementia subspecialty centers, and their charts were reviewed for the presence of clinical features described in the current criteria for FTLD. The proportion of patients with each clinical feature at the first clinical presentation was compared across groups. Results: A significantly larger proportion of patients with FTLD showed behavioral abnormalities, particularly social and personal conduct disorders and emotional blunting, than patients with AD. Few differences in language features were seen between the groups, and many of the language features detailed in the criteria were found in only a small proportion of patients. In both groups, many patients showed neuropsychological abnormalities, except for perceptual difficulties, which were present in many patients with AD but only in a few patients with FTLD. Extrapyramidal motor symptoms were more likely to be present in FTLD. Logistic regression revealed that five features-social conduct disorders, hyperorality, akinesia, absence of amnesia, and the absence of a perceptual disorder-correctly classified 93{\%} of patients with FTLD and 97{\%} of patients with AD. Conclusion: A combination of behavioral, neuropsychological, and physical findings is most useful in distinguishing FTLD from AD. Future studies should be directed at establishing more objective methods of identifying these clinical features.",
author = "Rosen, {H. J.} and Hartikainen, {K. M.} and W. Jagust and Kramer, {J. H.} and Reed, {Bruce R} and Cummings, {J. L.} and K. Boone and W. Ellis and C. Miller and Miller, {B. L.}",
year = "2002",
month = "6",
day = "11",
language = "English (US)",
volume = "58",
pages = "1608--1615",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD

AU - Rosen, H. J.

AU - Hartikainen, K. M.

AU - Jagust, W.

AU - Kramer, J. H.

AU - Reed, Bruce R

AU - Cummings, J. L.

AU - Boone, K.

AU - Ellis, W.

AU - Miller, C.

AU - Miller, B. L.

PY - 2002/6/11

Y1 - 2002/6/11

N2 - Objective: To assess the ability of the current diagnostic criteria for frontotemporal lobar degeneration (FTLD) to differentiate FTLD from AD. Methods: Thirty cases with autopsy-proven FTLD and 30 cases of AD, matched for Mini-Mental State Examination score, were identified from the clinical databases of three dementia subspecialty centers, and their charts were reviewed for the presence of clinical features described in the current criteria for FTLD. The proportion of patients with each clinical feature at the first clinical presentation was compared across groups. Results: A significantly larger proportion of patients with FTLD showed behavioral abnormalities, particularly social and personal conduct disorders and emotional blunting, than patients with AD. Few differences in language features were seen between the groups, and many of the language features detailed in the criteria were found in only a small proportion of patients. In both groups, many patients showed neuropsychological abnormalities, except for perceptual difficulties, which were present in many patients with AD but only in a few patients with FTLD. Extrapyramidal motor symptoms were more likely to be present in FTLD. Logistic regression revealed that five features-social conduct disorders, hyperorality, akinesia, absence of amnesia, and the absence of a perceptual disorder-correctly classified 93% of patients with FTLD and 97% of patients with AD. Conclusion: A combination of behavioral, neuropsychological, and physical findings is most useful in distinguishing FTLD from AD. Future studies should be directed at establishing more objective methods of identifying these clinical features.

AB - Objective: To assess the ability of the current diagnostic criteria for frontotemporal lobar degeneration (FTLD) to differentiate FTLD from AD. Methods: Thirty cases with autopsy-proven FTLD and 30 cases of AD, matched for Mini-Mental State Examination score, were identified from the clinical databases of three dementia subspecialty centers, and their charts were reviewed for the presence of clinical features described in the current criteria for FTLD. The proportion of patients with each clinical feature at the first clinical presentation was compared across groups. Results: A significantly larger proportion of patients with FTLD showed behavioral abnormalities, particularly social and personal conduct disorders and emotional blunting, than patients with AD. Few differences in language features were seen between the groups, and many of the language features detailed in the criteria were found in only a small proportion of patients. In both groups, many patients showed neuropsychological abnormalities, except for perceptual difficulties, which were present in many patients with AD but only in a few patients with FTLD. Extrapyramidal motor symptoms were more likely to be present in FTLD. Logistic regression revealed that five features-social conduct disorders, hyperorality, akinesia, absence of amnesia, and the absence of a perceptual disorder-correctly classified 93% of patients with FTLD and 97% of patients with AD. Conclusion: A combination of behavioral, neuropsychological, and physical findings is most useful in distinguishing FTLD from AD. Future studies should be directed at establishing more objective methods of identifying these clinical features.

UR - http://www.scopus.com/inward/record.url?scp=0037062568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037062568&partnerID=8YFLogxK

M3 - Article

C2 - 12058087

AN - SCOPUS:0037062568

VL - 58

SP - 1608

EP - 1615

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 11

ER -