Utf1: Goldilocks for ESC bivalency

Agnieszka I. Laskowski, Paul S Knoepfler

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Recently in Cell, Jia et al. (2012) reported novel Utf1-controlled mechanisms of maintaining pluripotency and self-renewal in embryonic stem cells (ESCs). Utf1 buffers bivalent gene expression by competitive binding with polycomb repressive complex 2 and initiation of mRNA degradation.

Original languageEnglish (US)
Pages (from-to)732-734
Number of pages3
JournalCell Stem Cell
Volume11
Issue number6
DOIs
StatePublished - Dec 7 2012

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine
  • Genetics

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