Ustekinumab to target granulomatous dermatitis in recalcitrant ulcerative necrobiosis lipoidica: Case report and proposed mechanism

Lauren A. Hassoun, Raja K Sivamani, Victoria R. Sharon, Marc Silverstein, Barbara A Burrall, Danielle Tartar

Research output: Contribution to journalLetterpeer-review

4 Scopus citations

Abstract

We present a 42-year-old woman with no history of diabetes or glucose intolerance who had a 5-year history of ulcerative necrobiosis lipoidica (NL). Despite failure of multiple medications, she experienced clearing of her ulcers after her treatment was changed to ustekinumab. We discuss our patient’s disease course and elaborate upon mechanistic reasons for her improvement related to ustekinumab therapy.

Original languageEnglish (US)
JournalDermatology Online Journal
Volume23
Issue number7
StatePublished - 2017

Keywords

  • Granulomatous dermatitis
  • IFNγ
  • Macrophage
  • Necrobiosis lipoidica
  • Th1
  • Ustekinumab

ASJC Scopus subject areas

  • Dermatology

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