Ustekinumab to target granulomatous dermatitis in recalcitrant ulcerative necrobiosis lipoidica: Case report and proposed mechanism

Lauren A. Hassoun; Raja K Sivamani; Victoria R. Sharon; Marc Silverstein; Barbara A Burrall; Danielle Tartar

Ustekinumab to target granulomatous dermatitis in recalcitrant ulcerative necrobiosis lipoidica: Case report and proposed mechanism

Lauren A. Hassoun, Raja K Sivamani, Victoria R. Sharon, Marc Silverstein, Barbara A Burrall, Danielle Tartar

Dermatology

Research output: Contribution to journal › Letter › peer-review

5 Scopus citations

Abstract

We present a 42-year-old woman with no history of diabetes or glucose intolerance who had a 5-year history of ulcerative necrobiosis lipoidica (NL). Despite failure of multiple medications, she experienced clearing of her ulcers after her treatment was changed to ustekinumab. We discuss our patient’s disease course and elaborate upon mechanistic reasons for her improvement related to ustekinumab therapy.

Original language	English (US)
Journal	Dermatology Online Journal
Volume	23
Issue number	7
State	Published - 2017

Keywords

Granulomatous dermatitis
IFNγ
Macrophage
Necrobiosis lipoidica
Th1
Ustekinumab

ASJC Scopus subject areas

Dermatology

Cite this

Ustekinumab to target granulomatous dermatitis in recalcitrant ulcerative necrobiosis lipoidica : Case report and proposed mechanism. / Hassoun, Lauren A.; Sivamani, Raja K; Sharon, Victoria R.; Silverstein, Marc ; Burrall, Barbara A ; Tartar, Danielle.

In: Dermatology Online Journal, Vol. 23, No. 7, 2017.

Research output: Contribution to journal › Letter › peer-review

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abstract = "We present a 42-year-old woman with no history of diabetes or glucose intolerance who had a 5-year history of ulcerative necrobiosis lipoidica (NL). Despite failure of multiple medications, she experienced clearing of her ulcers after her treatment was changed to ustekinumab. We discuss our patient{\textquoteright}s disease course and elaborate upon mechanistic reasons for her improvement related to ustekinumab therapy.",

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AU - Sharon, Victoria R.

AU - Silverstein, Marc

AU - Burrall, Barbara A

AU - Tartar, Danielle

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AB - We present a 42-year-old woman with no history of diabetes or glucose intolerance who had a 5-year history of ulcerative necrobiosis lipoidica (NL). Despite failure of multiple medications, she experienced clearing of her ulcers after her treatment was changed to ustekinumab. We discuss our patient’s disease course and elaborate upon mechanistic reasons for her improvement related to ustekinumab therapy.

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KW - IFNγ

KW - Macrophage

KW - Necrobiosis lipoidica

KW - Th1

KW - Ustekinumab

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ER -

Ustekinumab to target granulomatous dermatitis in recalcitrant ulcerative necrobiosis lipoidica: Case report and proposed mechanism

Abstract

Keywords

ASJC Scopus subject areas

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