Ustekinumab to target granulomatous dermatitis in recalcitrant ulcerative necrobiosis lipoidica: Case report and proposed mechanism

Lauren A. Hassoun, Raja K Sivamani, Victoria R. Sharon, Marc Silverstein, Barbara A Burrall, Danielle Tartar

Research output: Contribution to journalLetter

2 Citations (Scopus)

Abstract

We present a 42-year-old woman with no history of diabetes or glucose intolerance who had a 5-year history of ulcerative necrobiosis lipoidica (NL). Despite failure of multiple medications, she experienced clearing of her ulcers after her treatment was changed to ustekinumab. We discuss our patient’s disease course and elaborate upon mechanistic reasons for her improvement related to ustekinumab therapy.

Original languageEnglish (US)
JournalDermatology Online Journal
Volume23
Issue number7
StatePublished - 2017

Fingerprint

Necrobiosis Lipoidica
Dermatitis
Glucose Intolerance
Ulcer
Therapeutics
Ustekinumab

Keywords

  • Granulomatous dermatitis
  • IFNγ
  • Macrophage
  • Necrobiosis lipoidica
  • Th1
  • Ustekinumab

ASJC Scopus subject areas

  • Dermatology

Cite this

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title = "Ustekinumab to target granulomatous dermatitis in recalcitrant ulcerative necrobiosis lipoidica: Case report and proposed mechanism",
abstract = "We present a 42-year-old woman with no history of diabetes or glucose intolerance who had a 5-year history of ulcerative necrobiosis lipoidica (NL). Despite failure of multiple medications, she experienced clearing of her ulcers after her treatment was changed to ustekinumab. We discuss our patient’s disease course and elaborate upon mechanistic reasons for her improvement related to ustekinumab therapy.",
keywords = "Granulomatous dermatitis, IFNγ, Macrophage, Necrobiosis lipoidica, Th1, Ustekinumab",
author = "Hassoun, {Lauren A.} and Sivamani, {Raja K} and Sharon, {Victoria R.} and Marc Silverstein and Burrall, {Barbara A} and Danielle Tartar",
year = "2017",
language = "English (US)",
volume = "23",
journal = "Dermatology Online Journal",
issn = "1087-2108",
publisher = "Department of Dermatology UC Davis",
number = "7",

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TY - JOUR

T1 - Ustekinumab to target granulomatous dermatitis in recalcitrant ulcerative necrobiosis lipoidica

T2 - Case report and proposed mechanism

AU - Hassoun, Lauren A.

AU - Sivamani, Raja K

AU - Sharon, Victoria R.

AU - Silverstein, Marc

AU - Burrall, Barbara A

AU - Tartar, Danielle

PY - 2017

Y1 - 2017

N2 - We present a 42-year-old woman with no history of diabetes or glucose intolerance who had a 5-year history of ulcerative necrobiosis lipoidica (NL). Despite failure of multiple medications, she experienced clearing of her ulcers after her treatment was changed to ustekinumab. We discuss our patient’s disease course and elaborate upon mechanistic reasons for her improvement related to ustekinumab therapy.

AB - We present a 42-year-old woman with no history of diabetes or glucose intolerance who had a 5-year history of ulcerative necrobiosis lipoidica (NL). Despite failure of multiple medications, she experienced clearing of her ulcers after her treatment was changed to ustekinumab. We discuss our patient’s disease course and elaborate upon mechanistic reasons for her improvement related to ustekinumab therapy.

KW - Granulomatous dermatitis

KW - IFNγ

KW - Macrophage

KW - Necrobiosis lipoidica

KW - Th1

KW - Ustekinumab

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M3 - Letter

C2 - 29469709

AN - SCOPUS:85025705014

VL - 23

JO - Dermatology Online Journal

JF - Dermatology Online Journal

SN - 1087-2108

IS - 7

ER -