Using stable isotopes and isotope ratio mass spectrometry to study mineral metabolism in humans

Invited lecture

Ian J. Griffin

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Micronutrient deficiencies are enormous problems globally. Iron deficiency alone may affect 2 billion people, of whom at least 500 million are anaemic. Stable isotopes provide many methods to study mineral metabolism in humans. These range from relatively simple measurements of absorption, and endogenous faecal excretion, to complex studies using multi-compartmental modelling. Most studies use highly enriched stable isotope tracers administered intravenously and/or orally, coupled with precise measurements of the resulting isotopic enrichment in blood, urine or faeces. Stable isotope methodologies are becoming much more widely utilised due to the decreasing cost of isotopes and increasing acceptance of these methods. Two factors that have hampered broader use of stable isotope-based methods are the cost and limited availability of analytical methods that can measure isotope enrichments with sufficient precision, and at acceptable cost, in biological samples. In this article I will discuss the importance of micronutrient deficiencies globally, review some of the many stable isotope-based methodologies, and describe the analytical methods currently available. Highly enriched isotopes are becoming more available at acceptable cost. Currently, the greatest hurdle limiting wider use of stable isotope-based methods is the availability of sufficiently precise, accurate and cost-effective analysis of isotope ratios in biological samples. High-resolution inductively coupled plasma mass spectrometry (HR-ICP-MS), which is becoming more accessible, promises adequate precision at reasonable cost. It seems likely that HR-ICP-MS will be increasingly adopted as an analytical methodology, which will encourage collaborations between mass spectrometrists and clinicians/nutritionists. Such collaborations will benefit all participants, and increase understanding and knowledge about important micronutrient deficiencies worldwide.

Original languageEnglish (US)
Pages (from-to)1186-1193
Number of pages8
JournalJournal of Analytical Atomic Spectrometry
Volume17
Issue number9
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Metabolism
Isotopes
Minerals
Mass spectrometry
Micronutrients
Costs
Inductively coupled plasma mass spectrometry
Availability
Blood
Iron

ASJC Scopus subject areas

  • Spectroscopy

Cite this

Using stable isotopes and isotope ratio mass spectrometry to study mineral metabolism in humans : Invited lecture. / Griffin, Ian J.

In: Journal of Analytical Atomic Spectrometry, Vol. 17, No. 9, 2002, p. 1186-1193.

Research output: Contribution to journalArticle

@article{74dbd829f439434e861b8af1dbfbcd6b,
title = "Using stable isotopes and isotope ratio mass spectrometry to study mineral metabolism in humans: Invited lecture",
abstract = "Micronutrient deficiencies are enormous problems globally. Iron deficiency alone may affect 2 billion people, of whom at least 500 million are anaemic. Stable isotopes provide many methods to study mineral metabolism in humans. These range from relatively simple measurements of absorption, and endogenous faecal excretion, to complex studies using multi-compartmental modelling. Most studies use highly enriched stable isotope tracers administered intravenously and/or orally, coupled with precise measurements of the resulting isotopic enrichment in blood, urine or faeces. Stable isotope methodologies are becoming much more widely utilised due to the decreasing cost of isotopes and increasing acceptance of these methods. Two factors that have hampered broader use of stable isotope-based methods are the cost and limited availability of analytical methods that can measure isotope enrichments with sufficient precision, and at acceptable cost, in biological samples. In this article I will discuss the importance of micronutrient deficiencies globally, review some of the many stable isotope-based methodologies, and describe the analytical methods currently available. Highly enriched isotopes are becoming more available at acceptable cost. Currently, the greatest hurdle limiting wider use of stable isotope-based methods is the availability of sufficiently precise, accurate and cost-effective analysis of isotope ratios in biological samples. High-resolution inductively coupled plasma mass spectrometry (HR-ICP-MS), which is becoming more accessible, promises adequate precision at reasonable cost. It seems likely that HR-ICP-MS will be increasingly adopted as an analytical methodology, which will encourage collaborations between mass spectrometrists and clinicians/nutritionists. Such collaborations will benefit all participants, and increase understanding and knowledge about important micronutrient deficiencies worldwide.",
author = "Griffin, {Ian J.}",
year = "2002",
doi = "10.1039/b202249b",
language = "English (US)",
volume = "17",
pages = "1186--1193",
journal = "Journal of Analytical Atomic Spectrometry",
issn = "0267-9477",
publisher = "Royal Society of Chemistry",
number = "9",

}

TY - JOUR

T1 - Using stable isotopes and isotope ratio mass spectrometry to study mineral metabolism in humans

T2 - Invited lecture

AU - Griffin, Ian J.

PY - 2002

Y1 - 2002

N2 - Micronutrient deficiencies are enormous problems globally. Iron deficiency alone may affect 2 billion people, of whom at least 500 million are anaemic. Stable isotopes provide many methods to study mineral metabolism in humans. These range from relatively simple measurements of absorption, and endogenous faecal excretion, to complex studies using multi-compartmental modelling. Most studies use highly enriched stable isotope tracers administered intravenously and/or orally, coupled with precise measurements of the resulting isotopic enrichment in blood, urine or faeces. Stable isotope methodologies are becoming much more widely utilised due to the decreasing cost of isotopes and increasing acceptance of these methods. Two factors that have hampered broader use of stable isotope-based methods are the cost and limited availability of analytical methods that can measure isotope enrichments with sufficient precision, and at acceptable cost, in biological samples. In this article I will discuss the importance of micronutrient deficiencies globally, review some of the many stable isotope-based methodologies, and describe the analytical methods currently available. Highly enriched isotopes are becoming more available at acceptable cost. Currently, the greatest hurdle limiting wider use of stable isotope-based methods is the availability of sufficiently precise, accurate and cost-effective analysis of isotope ratios in biological samples. High-resolution inductively coupled plasma mass spectrometry (HR-ICP-MS), which is becoming more accessible, promises adequate precision at reasonable cost. It seems likely that HR-ICP-MS will be increasingly adopted as an analytical methodology, which will encourage collaborations between mass spectrometrists and clinicians/nutritionists. Such collaborations will benefit all participants, and increase understanding and knowledge about important micronutrient deficiencies worldwide.

AB - Micronutrient deficiencies are enormous problems globally. Iron deficiency alone may affect 2 billion people, of whom at least 500 million are anaemic. Stable isotopes provide many methods to study mineral metabolism in humans. These range from relatively simple measurements of absorption, and endogenous faecal excretion, to complex studies using multi-compartmental modelling. Most studies use highly enriched stable isotope tracers administered intravenously and/or orally, coupled with precise measurements of the resulting isotopic enrichment in blood, urine or faeces. Stable isotope methodologies are becoming much more widely utilised due to the decreasing cost of isotopes and increasing acceptance of these methods. Two factors that have hampered broader use of stable isotope-based methods are the cost and limited availability of analytical methods that can measure isotope enrichments with sufficient precision, and at acceptable cost, in biological samples. In this article I will discuss the importance of micronutrient deficiencies globally, review some of the many stable isotope-based methodologies, and describe the analytical methods currently available. Highly enriched isotopes are becoming more available at acceptable cost. Currently, the greatest hurdle limiting wider use of stable isotope-based methods is the availability of sufficiently precise, accurate and cost-effective analysis of isotope ratios in biological samples. High-resolution inductively coupled plasma mass spectrometry (HR-ICP-MS), which is becoming more accessible, promises adequate precision at reasonable cost. It seems likely that HR-ICP-MS will be increasingly adopted as an analytical methodology, which will encourage collaborations between mass spectrometrists and clinicians/nutritionists. Such collaborations will benefit all participants, and increase understanding and knowledge about important micronutrient deficiencies worldwide.

UR - http://www.scopus.com/inward/record.url?scp=0036739097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036739097&partnerID=8YFLogxK

U2 - 10.1039/b202249b

DO - 10.1039/b202249b

M3 - Article

VL - 17

SP - 1186

EP - 1193

JO - Journal of Analytical Atomic Spectrometry

JF - Journal of Analytical Atomic Spectrometry

SN - 0267-9477

IS - 9

ER -