Using Single-Channel Blind Deconvolution to Choose the Most Realistic Pharmacokinetic Model in Dynamic Contrast-Enhanced MR Imaging

Torfinn Taxt, Tina Pavlin, Rolf K. Reed, Fitz Roy Curry, Erling Andersen, Radovan Jiřík

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In dynamic contrast-enhanced magnetic resonance imaging, there has been no consensus in the choice of the pharmacokinetic model. In this paper, a new approach for assessment of the most realistic model for a given tissue is presented. Non-blind and single-channel blind deconvolution algorithms were used in quantitative magnetic resonance dynamic contrast-enhanced imaging of the mouse masseter muscle to compare the realism of two different pharmacokinetic models for the tissue residue function. The first was the adiabatic approximation tissue homogeneity model (aaJW) and the second, the two-compartment exchange model (2CXM). Normals and mice treated with the substance C48/80 were studied. C48/80 increases both blood flow and contrast leakage in muscle substantially. The obtained approximation accuracy was evaluated for both pharmacokinetic models. In addition, the arterial input functions (aifs) estimated using blind deconvolution were compared to the corresponding observed aifs. The hypothesis is that the most realistic model of the tissue residue function leads to the best fits. The non-blind deconvolution did not result in any clear answer. For blind deconvolution, the aifs of the aaJW model were very similar to the corresponding observed aifs, and clearly more so than the aifs of the 2CXM model. Also, the approximation of the observed tracer time sequences was more accurate for the aaJW than the 2CXM model. The realism of different pharmacokinetic models in describing the passage of a tracer through a microvascular bed of a single tissue could be assessed using single-channel blind deconvolution.

Original languageEnglish (US)
Pages (from-to)643-659
Number of pages17
JournalApplied Magnetic Resonance
Volume46
Issue number6
DOIs
StatePublished - Apr 21 2015

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muscles
tracers
mice
magnetic resonance
approximation
compartments
blood flow
homogeneity
beds
leakage

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Using Single-Channel Blind Deconvolution to Choose the Most Realistic Pharmacokinetic Model in Dynamic Contrast-Enhanced MR Imaging. / Taxt, Torfinn; Pavlin, Tina; Reed, Rolf K.; Curry, Fitz Roy; Andersen, Erling; Jiřík, Radovan.

In: Applied Magnetic Resonance, Vol. 46, No. 6, 21.04.2015, p. 643-659.

Research output: Contribution to journalArticle

Taxt, Torfinn ; Pavlin, Tina ; Reed, Rolf K. ; Curry, Fitz Roy ; Andersen, Erling ; Jiřík, Radovan. / Using Single-Channel Blind Deconvolution to Choose the Most Realistic Pharmacokinetic Model in Dynamic Contrast-Enhanced MR Imaging. In: Applied Magnetic Resonance. 2015 ; Vol. 46, No. 6. pp. 643-659.
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