Using electromyography to assess function in humans and animal models of muscular dystrophy

Jay J. Han, Gregory T. Carter, Michael D. Weiss, Chandra Shekar, Joseph N. Kornegay

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The available studies to date provide evidence of a role for NEMG as an in vivo, objective measurement tool to assess neuromuscular function without endangering the patient or requiring sacrifice of the animal model being studied. Our protocol for capturing and quantifying MUAPs in the mdx mouse support the role of EMG as sutiable objective test for therapeutic intervention trials. SEMG still remains somewhat difficult to quantify due to signal interference from skin and subcutaneous tissues, making it a less desirable tool. However, as computer technology evolves, SEMG may have a growing role in quantifying neuromuscular function, having all the advantages of NEMG plus the added benefit of being completely noninvasive. Coupling EMG findings with MR spectroscopy and imaging techniques in muscle allow a clinicician or investigator to get both physiologic and anatomic information of the neuromuscular system.

Original languageEnglish (US)
Pages (from-to)981-997
Number of pages17
JournalPhysical Medicine and Rehabilitation Clinics of North America
Volume16
Issue number4
DOIs
StatePublished - Nov 2005

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Animal Muscular Dystrophy
Inbred mdx Mouse
Subcutaneous Tissue
Electromyography
Information Systems
Magnetic Resonance Spectroscopy
Animal Models
Research Personnel
Technology
Muscles
Skin
Therapeutics

ASJC Scopus subject areas

  • Rehabilitation

Cite this

Using electromyography to assess function in humans and animal models of muscular dystrophy. / Han, Jay J.; Carter, Gregory T.; Weiss, Michael D.; Shekar, Chandra; Kornegay, Joseph N.

In: Physical Medicine and Rehabilitation Clinics of North America, Vol. 16, No. 4, 11.2005, p. 981-997.

Research output: Contribution to journalArticle

Han, Jay J. ; Carter, Gregory T. ; Weiss, Michael D. ; Shekar, Chandra ; Kornegay, Joseph N. / Using electromyography to assess function in humans and animal models of muscular dystrophy. In: Physical Medicine and Rehabilitation Clinics of North America. 2005 ; Vol. 16, No. 4. pp. 981-997.
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