USE OF TRANSITION-STATE THEORY IN THE DEVELOPMENT OF BIOACTIVE MOLECULES.

Yehia A I Abdel-Aal, Bruce D. Hammock

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Citations (Scopus)

Abstract

The application of transition state theory to enzyme catalysis is presented in terms of mechanistic and energetic approaches. A hypothesis is presented that the initial binding of some insecticidal carbamates and organophosphates to acetylcholinesterase is dependent in part upon their mimicking the transition state configuration of acetylcholine. As an indication of how transition state theory could be applied to problems in agricultural chemistry, the paper presents data that some trifluoromethylketone inhibitors of insect juvenile hormone esterase(s) are transition state mimics and applies a quantitative structure-activity relationship approach to these analogs.

Original languageEnglish (US)
Title of host publicationACS Symposium Series
Place of PublicationWashington, DC, USA
PublisherACS
Pages135-160
Number of pages26
ISBN (Print)0841209103
StatePublished - 1985

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Carbamates
Organophosphates
Acetylcholinesterase
Catalysis
Acetylcholine
Molecules
Enzymes
juvenile hormone esterase

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Abdel-Aal, Y. A. I., & Hammock, B. D. (1985). USE OF TRANSITION-STATE THEORY IN THE DEVELOPMENT OF BIOACTIVE MOLECULES. In ACS Symposium Series (pp. 135-160). Washington, DC, USA: ACS.

USE OF TRANSITION-STATE THEORY IN THE DEVELOPMENT OF BIOACTIVE MOLECULES. / Abdel-Aal, Yehia A I; Hammock, Bruce D.

ACS Symposium Series. Washington, DC, USA : ACS, 1985. p. 135-160.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abdel-Aal, YAI & Hammock, BD 1985, USE OF TRANSITION-STATE THEORY IN THE DEVELOPMENT OF BIOACTIVE MOLECULES. in ACS Symposium Series. ACS, Washington, DC, USA, pp. 135-160.
Abdel-Aal YAI, Hammock BD. USE OF TRANSITION-STATE THEORY IN THE DEVELOPMENT OF BIOACTIVE MOLECULES. In ACS Symposium Series. Washington, DC, USA: ACS. 1985. p. 135-160
Abdel-Aal, Yehia A I ; Hammock, Bruce D. / USE OF TRANSITION-STATE THEORY IN THE DEVELOPMENT OF BIOACTIVE MOLECULES. ACS Symposium Series. Washington, DC, USA : ACS, 1985. pp. 135-160
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