Abstract
The application of transition state theory to enzyme catalysis is presented in terms of mechanistic and energetic approaches. A hypothesis is presented that the initial binding of some insecticidal carbamates and organophosphates to acetylcholinesterase is dependent in part upon their mimicking the transition state configuration of acetylcholine. As an indication of how transition state theory could be applied to problems in agricultural chemistry, the paper presents data that some trifluoromethylketone inhibitors of insect juvenile hormone esterase(s) are transition state mimics and applies a quantitative structure-activity relationship approach to these analogs.
| Original language | English (US) |
|---|---|
| Title of host publication | ACS Symposium Series |
| Place of Publication | Washington, DC, USA |
| Publisher | ACS |
| Pages | 135-160 |
| Number of pages | 26 |
| ISBN (Print) | 0841209103 |
| State | Published - 1985 |
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ASJC Scopus subject areas
- Chemistry(all)
Cite this
USE OF TRANSITION-STATE THEORY IN THE DEVELOPMENT OF BIOACTIVE MOLECULES. / Abdel-Aal, Yehia A I; Hammock, Bruce D.
ACS Symposium Series. Washington, DC, USA : ACS, 1985. p. 135-160.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
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TY - GEN
T1 - USE OF TRANSITION-STATE THEORY IN THE DEVELOPMENT OF BIOACTIVE MOLECULES.
AU - Abdel-Aal, Yehia A I
AU - Hammock, Bruce D.
PY - 1985
Y1 - 1985
N2 - The application of transition state theory to enzyme catalysis is presented in terms of mechanistic and energetic approaches. A hypothesis is presented that the initial binding of some insecticidal carbamates and organophosphates to acetylcholinesterase is dependent in part upon their mimicking the transition state configuration of acetylcholine. As an indication of how transition state theory could be applied to problems in agricultural chemistry, the paper presents data that some trifluoromethylketone inhibitors of insect juvenile hormone esterase(s) are transition state mimics and applies a quantitative structure-activity relationship approach to these analogs.
AB - The application of transition state theory to enzyme catalysis is presented in terms of mechanistic and energetic approaches. A hypothesis is presented that the initial binding of some insecticidal carbamates and organophosphates to acetylcholinesterase is dependent in part upon their mimicking the transition state configuration of acetylcholine. As an indication of how transition state theory could be applied to problems in agricultural chemistry, the paper presents data that some trifluoromethylketone inhibitors of insect juvenile hormone esterase(s) are transition state mimics and applies a quantitative structure-activity relationship approach to these analogs.
UR - http://www.scopus.com/inward/record.url?scp=0021850944&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021850944&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:0021850944
SN - 0841209103
SP - 135
EP - 160
BT - ACS Symposium Series
PB - ACS
CY - Washington, DC, USA
ER -