Use of radiologic modalities in coccidioidal meningitis

R. C. Stadalnik, E. Goldstein, P. D. Hoeprich, John P McGahan

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The diagnostic utility of pentetate indium trisodium in 111 CSF studies, technetium Tc 99m brain scans, and computerized tomographic (CT) scans was evaluated in eight patients in whom coccidioidal meningitis developed following a dust storm in the Central Valley of California. The 111In flow studies and the CT scans demonstrated hydrocephalus in five patients with clinical findings suggesting this complication. Ventriculitis has not previously been diagnosed before death in patients with coccidioidal meningitis; however, it was demonstrated in two patients by the technetium Tc 99m brain scan. Basal meningitis, which is indicative of fungal infection, is also detectable on contrast-enhanced CT scan. The finding that communicating hydrocephalus occurs early in meningitis and interferes with CSF flow into infected basilar regions has important therapeutic implications in that antifungal agents injected into the lumbar subarachnoid space may not reach these regions.

Original languageEnglish (US)
Pages (from-to)75-78
Number of pages4
JournalArchives of Internal Medicine
Volume141
Issue number1
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Internal Medicine

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