Use of Pelvic Flexure Biopsy Scores to Predict Short-Term Survival after Large Colon Volvulus

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To (1) determine if histologic scores of pelvic flexure biopsies can predict short-term survival in horses with large colon volvulus (LCV) and (2) identify clinical variables predictive of short-term survival. Study Design: Case series. Animals: Horses (n = 28) with LCV (≥360°). Methods: Medical records (January 2000-February 2008) of 28 horses were reviewed and clinical data recorded. Pelvic flexure biopsies were reviewed by 2 board-certified veterinary pathologists, unaware of clinical history and outcome, using 2 scoring systems. Exact logistic regression analysis was used to determine the relationship between histopathology scores (tissue viability), clinical data, and short-term survival (hospital discharge). Results: Twenty-four horses (86%) survived to hospital discharge. Using a similar cutoff, neither scoring system was capable of predicting short-term survival. One scoring system failed to correctly predict clinical outcome in 5/25 horses (20%) and the other failed in 6/28 horses (22.4%). Heart rate (at admission and 24 hours after surgery) and packed cell volume 24 hours after surgery were significantly associated with short-term survival. Conclusion: Histopathologic evaluation of pelvic flexure biopsies did not accurately predict short-term survival in a significant proportion of horses with LCV in this study.

Original languageEnglish (US)
Pages (from-to)582-588
Number of pages7
JournalVeterinary Surgery
Volume41
Issue number5
DOIs
StatePublished - Jul 2012

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volvulus
Intestinal Volvulus
Horses
colon
biopsy
Colon
Biopsy
horses
surgery
Tissue Survival
Cell Size
histopathology
hematocrit
Medical Records
heart rate
regression analysis
Heart Rate
Logistic Models
experimental design
Regression Analysis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Use of Pelvic Flexure Biopsy Scores to Predict Short-Term Survival after Large Colon Volvulus. / Levi, Ohad; Affolter, Verena K; Benak, Jaromir; Kass, Philip H; Le jeune, Sonia S.

In: Veterinary Surgery, Vol. 41, No. 5, 07.2012, p. 582-588.

Research output: Contribution to journalArticle

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abstract = "Objective: To (1) determine if histologic scores of pelvic flexure biopsies can predict short-term survival in horses with large colon volvulus (LCV) and (2) identify clinical variables predictive of short-term survival. Study Design: Case series. Animals: Horses (n = 28) with LCV (≥360°). Methods: Medical records (January 2000-February 2008) of 28 horses were reviewed and clinical data recorded. Pelvic flexure biopsies were reviewed by 2 board-certified veterinary pathologists, unaware of clinical history and outcome, using 2 scoring systems. Exact logistic regression analysis was used to determine the relationship between histopathology scores (tissue viability), clinical data, and short-term survival (hospital discharge). Results: Twenty-four horses (86{\%}) survived to hospital discharge. Using a similar cutoff, neither scoring system was capable of predicting short-term survival. One scoring system failed to correctly predict clinical outcome in 5/25 horses (20{\%}) and the other failed in 6/28 horses (22.4{\%}). Heart rate (at admission and 24 hours after surgery) and packed cell volume 24 hours after surgery were significantly associated with short-term survival. Conclusion: Histopathologic evaluation of pelvic flexure biopsies did not accurately predict short-term survival in a significant proportion of horses with LCV in this study.",
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AU - Le jeune, Sonia S

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