Use of neuroendocrine hormones to promote reconstitution after bone marrow transplantation

Mary A. Woody, Lisbeth A. Welniak, Susan Richards, Dennis D. Taub, Zhi Gang Tian, Rui Sun, Dan L. Longo, William J Murphy

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

A survey of the previous literature and the data shown here indicate that neuroendocrine hormones such as growth hormone and prolactin may be of potential clinical use after bone marrow transplantation (BMT) to promote hematopoietic and immune recovery. The amounts of hormones used in our model do not promote weight gain suggesting that their lymphohematopoietic actions were independent of their anabolic effects. While the hormones may not produce the same extent of immune/hematopoietic effects when compared to conventional hematopoietic and immune stimulating cytokines (i.e. IL-2 or G- CSF), their pleiotropic effects and limited toxicity after systemic administration makes them attractive to test in the post-BMT setting. However, more work needs to be performed to understand the mechanism(s) of their action, particularly with regard to T-cell function and development.

Original languageEnglish (US)
Pages (from-to)69-80
Number of pages12
JournalNeuroImmunoModulation
Volume6
Issue number1-2
DOIs
StatePublished - Jan 1999
Externally publishedYes

Keywords

  • Growth hormone
  • Hematopoiesis
  • Immune parameters
  • Prolactin
  • Transplantation

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Immunology

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  • Cite this

    Woody, M. A., Welniak, L. A., Richards, S., Taub, D. D., Tian, Z. G., Sun, R., Longo, D. L., & Murphy, W. J. (1999). Use of neuroendocrine hormones to promote reconstitution after bone marrow transplantation. NeuroImmunoModulation, 6(1-2), 69-80. https://doi.org/10.1159/000026366