Use of mitomycin C in the pediatric airway

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Purpose of review: Mitomycin C was not used in the field of otolaryngology before 1998. Currently it is commonly used by all pediatric otolaryngologists dealing with airway stenoses. Mitomycin C offers the surgeon a method of modifying healing and diminishing granulation tissue and cicatricial scar. Recent findings: There are numerous animal studies showing the beneficial effect of mitomycin C on wound healing in the airway. The human studies rarely have controls and in many cases are case reports. Human studies typically use dosages commonly used in ophthalmology, which are in the low range in relation to the animal airway studies. Summary: This article attempts to summarize the available research on mitomycin C, helping the clinical otolaryngologist choose the proper dosage, indications, and frequency of use.

Original languageEnglish (US)
Pages (from-to)473-475
Number of pages3
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Issue number6
StatePublished - Dec 2004


  • Choanal atresia
  • Granulation tissue
  • Mitomycin
  • Subglottic stenosis
  • Tracheal stenosis

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery


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