Use of kv1.3 blockers for inflammatory skin conditions

W. Nguyen, B. L. Howard, D. S. Neale, P. E. Thompson, P. J. White, Heike Wulff, D. T. Manallack

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Recent results using animal models of inflammatory skin conditions have shown that blockers of the voltage-gated potassium channel, Kv1.3 hold great promise for clinical utility. Kv1.3 blockers act as immunosuppressants by modulating the various subsets of inflammatory T and B cells involved in autoimmune disorders. While peptidic inhibitors based on naturally occurring venoms demonstrate potent and selective Kv1.3 blockade, these require parenteral administration and may face potential immunogenicity problems. Small molecule blockers show considerable diversity, however selectivity over other Kv1-family channels has been difficult to achieve. More recent advances have added to the evidence that Kv1.3 channels are a suitable therapeutic target and that the development of novel and selective agents will herald new drugs for inflammatory skin disorders.

Original languageEnglish (US)
Pages (from-to)2882-2896
Number of pages15
JournalCurrent Medicinal Chemistry
Volume17
Issue number26
DOIs
StatePublished - 2010

Keywords

  • Autoimmune disorder
  • Drug design
  • Inflammation
  • Kv1.3 channel
  • Psoriasis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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  • Cite this

    Nguyen, W., Howard, B. L., Neale, D. S., Thompson, P. E., White, P. J., Wulff, H., & Manallack, D. T. (2010). Use of kv1.3 blockers for inflammatory skin conditions. Current Medicinal Chemistry, 17(26), 2882-2896. https://doi.org/10.2174/092986710792065072