Use of ketorolac is associated with decreased pneumonia following rib fractures

Yifan Yang, Jason B. Young, Carol R. Schermer, Garth H Utter

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background The effectiveness of the nonsteroidal anti-inflammatory drug ketorolac in reducing pulmonary morbidity after rib fractures remains largely unknown. Methods A retrospective cohort study was conducted spanning January 2003 to June 2011 assessing pneumonia within 30 days and potential adverse effects of ketorolac among all patients with rib fractures who received ketorolac <4 days after injury compared with a random sample of those who did not. Results Among 202 patients who received ketorolac and 417 who did not, ketorolac use was associated with decreased pneumonia (odds ratio,.14; 95% confidence interval,.04 to.46) and increased ventilator-free days (difference, 1.8 days; 95% confidence interval, 1.1 to 2.5) and intensive care unit-free days (difference, 2.1 days; 95% confidence interval, 1.3 to 3.0) within 30 days. The rates of acute kidney injury, gastrointestinal hemorrhage, and fracture nonunion were not different. Conclusions Early administration of ketorolac to patients with rib fractures is associated with a decreased likelihood of pneumonia, without apparent risks.

Original languageEnglish (US)
Pages (from-to)566-572
Number of pages7
JournalAmerican Journal of Surgery
Volume207
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Ketorolac
Rib Fractures
Pneumonia
Confidence Intervals
Gastrointestinal Hemorrhage
Mechanical Ventilators
Acute Kidney Injury
Intensive Care Units
Cohort Studies
Anti-Inflammatory Agents
Retrospective Studies
Odds Ratio
Morbidity
Lung
Wounds and Injuries
Pharmaceutical Preparations

Keywords

  • Analgesia
  • Ketorolac
  • Nonsteroidal anti-inflammatory drug
  • Pneumonia
  • Pulmonary complication
  • Rib fractures

ASJC Scopus subject areas

  • Surgery

Cite this

Use of ketorolac is associated with decreased pneumonia following rib fractures. / Yang, Yifan; Young, Jason B.; Schermer, Carol R.; Utter, Garth H.

In: American Journal of Surgery, Vol. 207, No. 4, 2014, p. 566-572.

Research output: Contribution to journalArticle

Yang, Yifan ; Young, Jason B. ; Schermer, Carol R. ; Utter, Garth H. / Use of ketorolac is associated with decreased pneumonia following rib fractures. In: American Journal of Surgery. 2014 ; Vol. 207, No. 4. pp. 566-572.
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N2 - Background The effectiveness of the nonsteroidal anti-inflammatory drug ketorolac in reducing pulmonary morbidity after rib fractures remains largely unknown. Methods A retrospective cohort study was conducted spanning January 2003 to June 2011 assessing pneumonia within 30 days and potential adverse effects of ketorolac among all patients with rib fractures who received ketorolac <4 days after injury compared with a random sample of those who did not. Results Among 202 patients who received ketorolac and 417 who did not, ketorolac use was associated with decreased pneumonia (odds ratio,.14; 95% confidence interval,.04 to.46) and increased ventilator-free days (difference, 1.8 days; 95% confidence interval, 1.1 to 2.5) and intensive care unit-free days (difference, 2.1 days; 95% confidence interval, 1.3 to 3.0) within 30 days. The rates of acute kidney injury, gastrointestinal hemorrhage, and fracture nonunion were not different. Conclusions Early administration of ketorolac to patients with rib fractures is associated with a decreased likelihood of pneumonia, without apparent risks.

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