Use of isotretinoin and etretinate for the treatment of benign cutaneous neoplasia and cutaneous lymphoma in dogs

Stephen D White, R. A W Rosychuk, K. V. Scott, A. L. Trettien, L. Jonas, P. Denerolle

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

The purpose of this study was to evaluate the synthetic retinoids isotretinoin and etretinate to treat dogs with intracutaneous cornifying epitheliomas (ICE), other benign skin neoplasias, and cutaneous lymphoma. Twenty-four dogs were used. All tumors were diagnosed by histologic examination. Ten dogs with multiple (at least 5) benign skin tumors (7 with ICE, 1 each with inverted papillomas, sebaceous adenomas and epidermal cysts) were treated with isotretinoin (n = 7) and/or etretinate (n = 5). Twelve dogs with cutaneous lymphoma were treated with isotretinoin, and 2 dogs with cutaneous lymphoma were initially treated with etretinate. Successful treatment with isotretinoin was achieved in 1 dog with ICE, 1 with inverted papillomas, and 1 with epidermal cysts. Partial improvement with isotretinoin was seen in 2 dogs with ICE. Successful treatment was achieved with etretinate in 4 dogs with ICE (Norwegian Elkhound was the predominant breed with ICE). Remission was achieved in 6 of the 14 dogs with cutaneous lymphoma. Averse effects developed in 7 of the 24 dogs, so treatment was stopped in 2 dogs.

Original languageEnglish (US)
Pages (from-to)387-391
Number of pages5
JournalJournal of the American Veterinary Medical Association
Volume202
Issue number3
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)

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