Use of insulin glargine in 2 dogs with diabetes mellitus

Jin Ok Ahn, Kyoung Won Seo, Cheol Yong Hwang, Hwa Young Youn

Research output: Contribution to journalArticle

Abstract

A Spitz (5-years old, castrated male) and a Maltese (9-years old, castrated male) were presented with weight loss, polyuria/polydipsia (PU/PD) and depression. Diabetic ketosis was diagnosed based on clinical signs, physical examinations and screening tests (CBC, serum chemistry and urinalysis). The dogs were treated with NPH initially. However, NPH was inadequate to control blood glucose level due to the short duration of the action (< 5 hours). Because of the poor glycemic control with NPH, the dogs showed diabetic complications including weight loss and cataract. After change to glargine, the duration of insulin action was extended up to 11 hours. As a result, there was significant improvement in clinical signs and serum fructosamine concentrations. This study suggests that glargine is useful as a long-acting insulin in dogs which have poor glycemic control due to the short duration of NPH.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalJournal of Veterinary Clinics
Volume28
Issue number1
StatePublished - Feb 1 2011
Externally publishedYes

Fingerprint

diabetes mellitus
Diabetes Mellitus
glycemic control
insulin
Dogs
duration
Weight Loss
dogs
weight loss
Long-Acting Insulin
Fructosamine
Polydipsia
Polyuria
Diabetic Ketoacidosis
blood chemistry
ketosis
Urinalysis
urinalysis
cataract
Diabetes Complications

Keywords

  • Diabetes mellitus
  • Dog
  • Glargine
  • Insulin

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Ahn, J. O., Seo, K. W., Hwang, C. Y., & Youn, H. Y. (2011). Use of insulin glargine in 2 dogs with diabetes mellitus. Journal of Veterinary Clinics, 28(1), 139-143.

Use of insulin glargine in 2 dogs with diabetes mellitus. / Ahn, Jin Ok; Seo, Kyoung Won; Hwang, Cheol Yong; Youn, Hwa Young.

In: Journal of Veterinary Clinics, Vol. 28, No. 1, 01.02.2011, p. 139-143.

Research output: Contribution to journalArticle

Ahn, JO, Seo, KW, Hwang, CY & Youn, HY 2011, 'Use of insulin glargine in 2 dogs with diabetes mellitus', Journal of Veterinary Clinics, vol. 28, no. 1, pp. 139-143.
Ahn, Jin Ok ; Seo, Kyoung Won ; Hwang, Cheol Yong ; Youn, Hwa Young. / Use of insulin glargine in 2 dogs with diabetes mellitus. In: Journal of Veterinary Clinics. 2011 ; Vol. 28, No. 1. pp. 139-143.
@article{a325138379944f9c8218f61f3f7a9fbf,
title = "Use of insulin glargine in 2 dogs with diabetes mellitus",
abstract = "A Spitz (5-years old, castrated male) and a Maltese (9-years old, castrated male) were presented with weight loss, polyuria/polydipsia (PU/PD) and depression. Diabetic ketosis was diagnosed based on clinical signs, physical examinations and screening tests (CBC, serum chemistry and urinalysis). The dogs were treated with NPH initially. However, NPH was inadequate to control blood glucose level due to the short duration of the action (< 5 hours). Because of the poor glycemic control with NPH, the dogs showed diabetic complications including weight loss and cataract. After change to glargine, the duration of insulin action was extended up to 11 hours. As a result, there was significant improvement in clinical signs and serum fructosamine concentrations. This study suggests that glargine is useful as a long-acting insulin in dogs which have poor glycemic control due to the short duration of NPH.",
keywords = "Diabetes mellitus, Dog, Glargine, Insulin",
author = "Ahn, {Jin Ok} and Seo, {Kyoung Won} and Hwang, {Cheol Yong} and Youn, {Hwa Young}",
year = "2011",
month = "2",
day = "1",
language = "English (US)",
volume = "28",
pages = "139--143",
journal = "Journal of Veterinary Clinics",
issn = "1598-298X",
publisher = "Korean Society of Veterinary Clinics",
number = "1",

}

TY - JOUR

T1 - Use of insulin glargine in 2 dogs with diabetes mellitus

AU - Ahn, Jin Ok

AU - Seo, Kyoung Won

AU - Hwang, Cheol Yong

AU - Youn, Hwa Young

PY - 2011/2/1

Y1 - 2011/2/1

N2 - A Spitz (5-years old, castrated male) and a Maltese (9-years old, castrated male) were presented with weight loss, polyuria/polydipsia (PU/PD) and depression. Diabetic ketosis was diagnosed based on clinical signs, physical examinations and screening tests (CBC, serum chemistry and urinalysis). The dogs were treated with NPH initially. However, NPH was inadequate to control blood glucose level due to the short duration of the action (< 5 hours). Because of the poor glycemic control with NPH, the dogs showed diabetic complications including weight loss and cataract. After change to glargine, the duration of insulin action was extended up to 11 hours. As a result, there was significant improvement in clinical signs and serum fructosamine concentrations. This study suggests that glargine is useful as a long-acting insulin in dogs which have poor glycemic control due to the short duration of NPH.

AB - A Spitz (5-years old, castrated male) and a Maltese (9-years old, castrated male) were presented with weight loss, polyuria/polydipsia (PU/PD) and depression. Diabetic ketosis was diagnosed based on clinical signs, physical examinations and screening tests (CBC, serum chemistry and urinalysis). The dogs were treated with NPH initially. However, NPH was inadequate to control blood glucose level due to the short duration of the action (< 5 hours). Because of the poor glycemic control with NPH, the dogs showed diabetic complications including weight loss and cataract. After change to glargine, the duration of insulin action was extended up to 11 hours. As a result, there was significant improvement in clinical signs and serum fructosamine concentrations. This study suggests that glargine is useful as a long-acting insulin in dogs which have poor glycemic control due to the short duration of NPH.

KW - Diabetes mellitus

KW - Dog

KW - Glargine

KW - Insulin

UR - http://www.scopus.com/inward/record.url?scp=79959361286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959361286&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:79959361286

VL - 28

SP - 139

EP - 143

JO - Journal of Veterinary Clinics

JF - Journal of Veterinary Clinics

SN - 1598-298X

IS - 1

ER -