Abstract
A Spitz (5-years old, castrated male) and a Maltese (9-years old, castrated male) were presented with weight loss, polyuria/polydipsia (PU/PD) and depression. Diabetic ketosis was diagnosed based on clinical signs, physical examinations and screening tests (CBC, serum chemistry and urinalysis). The dogs were treated with NPH initially. However, NPH was inadequate to control blood glucose level due to the short duration of the action (< 5 hours). Because of the poor glycemic control with NPH, the dogs showed diabetic complications including weight loss and cataract. After change to glargine, the duration of insulin action was extended up to 11 hours. As a result, there was significant improvement in clinical signs and serum fructosamine concentrations. This study suggests that glargine is useful as a long-acting insulin in dogs which have poor glycemic control due to the short duration of NPH.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 139-143 |
| Number of pages | 5 |
| Journal | Journal of Veterinary Clinics |
| Volume | 28 |
| Issue number | 1 |
| State | Published - Feb 1 2011 |
| Externally published | Yes |
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Keywords
- Diabetes mellitus
- Dog
- Glargine
- Insulin
ASJC Scopus subject areas
- veterinary(all)
Cite this
Use of insulin glargine in 2 dogs with diabetes mellitus. / Ahn, Jin Ok; Seo, Kyoung Won; Hwang, Cheol Yong; Youn, Hwa Young.
In: Journal of Veterinary Clinics, Vol. 28, No. 1, 01.02.2011, p. 139-143.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Use of insulin glargine in 2 dogs with diabetes mellitus
AU - Ahn, Jin Ok
AU - Seo, Kyoung Won
AU - Hwang, Cheol Yong
AU - Youn, Hwa Young
PY - 2011/2/1
Y1 - 2011/2/1
N2 - A Spitz (5-years old, castrated male) and a Maltese (9-years old, castrated male) were presented with weight loss, polyuria/polydipsia (PU/PD) and depression. Diabetic ketosis was diagnosed based on clinical signs, physical examinations and screening tests (CBC, serum chemistry and urinalysis). The dogs were treated with NPH initially. However, NPH was inadequate to control blood glucose level due to the short duration of the action (< 5 hours). Because of the poor glycemic control with NPH, the dogs showed diabetic complications including weight loss and cataract. After change to glargine, the duration of insulin action was extended up to 11 hours. As a result, there was significant improvement in clinical signs and serum fructosamine concentrations. This study suggests that glargine is useful as a long-acting insulin in dogs which have poor glycemic control due to the short duration of NPH.
AB - A Spitz (5-years old, castrated male) and a Maltese (9-years old, castrated male) were presented with weight loss, polyuria/polydipsia (PU/PD) and depression. Diabetic ketosis was diagnosed based on clinical signs, physical examinations and screening tests (CBC, serum chemistry and urinalysis). The dogs were treated with NPH initially. However, NPH was inadequate to control blood glucose level due to the short duration of the action (< 5 hours). Because of the poor glycemic control with NPH, the dogs showed diabetic complications including weight loss and cataract. After change to glargine, the duration of insulin action was extended up to 11 hours. As a result, there was significant improvement in clinical signs and serum fructosamine concentrations. This study suggests that glargine is useful as a long-acting insulin in dogs which have poor glycemic control due to the short duration of NPH.
KW - Diabetes mellitus
KW - Dog
KW - Glargine
KW - Insulin
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UR - http://www.scopus.com/inward/citedby.url?scp=79959361286&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:79959361286
VL - 28
SP - 139
EP - 143
JO - Journal of Veterinary Clinics
JF - Journal of Veterinary Clinics
SN - 1598-298X
IS - 1
ER -